国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2015年
3期
283-286
,共4页
全身麻醉%睡眠%下丘脑腹外侧视前核%γ-氨基丁酸
全身痳醉%睡眠%下丘腦腹外側視前覈%γ-氨基丁痠
전신마취%수면%하구뇌복외측시전핵%γ-안기정산
General anesthesia%Sleep%Ventrolateral preoptic nucleus%γ-aminobutyric acid
背景 全身麻醉与自然睡眠之间存在一定的相似性,但睡眠-觉醒核团是否参与全身麻醉药物致意识消失的过程目前仍未有定论. 目的 综述睡眠-觉醒通路中主要的促睡眠核团下丘脑腹外侧视前核(ventrolateral preoptic nucleus,VLPO)及其相关通路与全身麻醉机制之间的关系. 内容 全身麻醉药可能会通过兴奋主要的促睡眠核团和抑制关键的促觉醒核团产生镇静催眠效应. 趋向 探讨全身麻醉药物作用于睡眠核团及其相关通路的生理机制,为全身麻醉机制研究提供一新的思路.
揹景 全身痳醉與自然睡眠之間存在一定的相似性,但睡眠-覺醒覈糰是否參與全身痳醉藥物緻意識消失的過程目前仍未有定論. 目的 綜述睡眠-覺醒通路中主要的促睡眠覈糰下丘腦腹外側視前覈(ventrolateral preoptic nucleus,VLPO)及其相關通路與全身痳醉機製之間的關繫. 內容 全身痳醉藥可能會通過興奮主要的促睡眠覈糰和抑製關鍵的促覺醒覈糰產生鎮靜催眠效應. 趨嚮 探討全身痳醉藥物作用于睡眠覈糰及其相關通路的生理機製,為全身痳醉機製研究提供一新的思路.
배경 전신마취여자연수면지간존재일정적상사성,단수면-각성핵단시부삼여전신마취약물치의식소실적과정목전잉미유정론. 목적 종술수면-각성통로중주요적촉수면핵단하구뇌복외측시전핵(ventrolateral preoptic nucleus,VLPO)급기상관통로여전신마취궤제지간적관계. 내용 전신마취약가능회통과흥강주요적촉수면핵단화억제관건적촉각성핵단산생진정최면효응. 추향 탐토전신마취약물작용우수면핵단급기상관통로적생리궤제,위전신마취궤제연구제공일신적사로.
Background There are certain similarities between general anesthesia and physiological sleep.However,it is still controversial whether sleep-active nucleus are involved in general anesthesia.Objective To review the relationship between ventrolateral preoptic nucleus (VLPO) as well as related pathways and general anesthesia.Content General anesthetics may stimulate main sleep-active nucleus and inhibit key arousal nucleus thus exert their sedate and hypnotic effects.Trend To explore the mechanisms of general anesthesia,and to find the potential targets of general anesthetics,thus providing new ideas for the research of general anesthesia.
