CAJ | 학술논문

目的：观察可吸收防粘连液对大鼠实验性腹壁粘连的抑制作用。方法：60只SD大鼠随机分为生理盐水组（A组）、医用透明质酸钠凝胶组（B组）、可吸收防粘连液组（C组）3组，每组20只，制作大鼠腹壁缺损/盲肠刮伤模型，在造模后第7和第14天处死大鼠，观察粘连分级积分、解剖学、病理组织学改变。结果：可吸收防粘连液显著抑制大鼠实验性腹壁粘连，降低粘连分级积分；减少炎细胞浸润和炎性肉芽组织增生，浆膜层组织变性较轻。结论：可吸收防粘连液在一定程度抑制术后粘连。
목적：관찰가흡수방점련액대대서실험성복벽점련적억제작용。방법：60지SD대서수궤분위생리염수조（A조）、의용투명질산납응효조（B조）、가흡수방점련액조（C조）3조，매조20지，제작대서복벽결손/맹장괄상모형，재조모후제7화제14천처사대서，관찰점련분급적분、해부학、병리조직학개변。결과：가흡수방점련액현저억제대서실험성복벽점련，강저점련분급적분；감소염세포침윤화염성육아조직증생，장막층조직변성교경。결론：가흡수방점련액재일정정도억제술후점련。
Objective:To investigate the inhibitory effect of absorbable anti-adhesion fluid on experi-mental abdominal adhesion in rats. Methods:Sixty SD rats were randomly divided into 3 groups as following:normal saline group( group A),medical sodium hyaluronate gel group( group B),and ab-sorbable anti-adhesion fluid group( group C ). The abdominal wall defect and cecal abrasion model was establiehsed. After 7 d and 14 d of operation,the rats were sacrificed and the following indexes in-cluding adhesion classification, gross anatomy observation, and histopathologic examination were checked. Results:The adhesion classification was significant decreased in group C,there were signifi-cant differences compared to group A( P <0. 05 ). Histopathological examination confirmed that ab-sorbable anti-adhesion fluid could attenuate inflammatory cell infiltration,granulation tissue prolifera-tion,and serosal tissue degeneration. Conclusions:Absorbable anti-adhesion fluid can inhibit adhe-sion after operation.