CAJ | 학술논문

目的：测定紫茎泽兰乙醇提取物的半数致死量。方法取昆明种小鼠灌胃给药，首先通过预实验，找出紫茎泽兰乙醇提取物的0%和100%致死剂量（Dmin、Dmax），以此作为依据，计算正式实验分组的组距；再通过正式实验观察并详细记录动物的反应和死亡情况，选择统计学软件 SPSS 17.0机率单位加权回归法（Bliss）法计算 LD50。结果紫茎泽兰的 LD50为126.3 g·kg-1，95%可信区间为107.8~146.6 g·kg-1。结论紫茎泽兰毒性较大。
목적：측정자경택란을순제취물적반수치사량。방법취곤명충소서관위급약，수선통과예실험，조출자경택란을순제취물적0%화100%치사제량（Dmin、Dmax），이차작위의거，계산정식실험분조적조거；재통과정식실험관찰병상세기록동물적반응화사망정황，선택통계학연건 SPSS 17.0궤솔단위가권회귀법（Bliss）법계산 LD50。결과자경택란적 LD50위126.3 g·kg-1，95%가신구간위107.8~146.6 g·kg-1。결론자경택란독성교대。
Objective To measure the LD50 of ethanol extracts of Eupatorium adenophorum Spreng. Methods Kunming mice were given the ethanol extracts of Eupatorium adenophorum Spreng by intragastric administration. Through the pre experiment, to find out the 0% and 100% lethal dose (Dmin , Dmax) of ethanol extracts of Eupatorium adenophorum Spreng, as a basis for the formal test, to calculate the group distance of experimental group. The detailed reactions and death results of mice were observed and recorded through the formal test, LD50 was calculated with probit weighted regression method (Bliss) by the SPSS 17.0 statistics software. Results LD50 of Eupatorium adenophorum Spreng was 126.3 g·kg -1, and 95% confidence interval was 107.8 ~146.6 g·kg -1. Conclusion The toxicity of Eupatorium adenophorum Spreng is higher.