CAJ | 학술논문

目的：制备辣椒碱-β-环糊精包合物，考察其溶解度。方法采用共沉淀法制备包合物，用正交设计优化包合物形成的最佳条件，采用相溶解度法测定包合物的表观溶解度和包合稳定常数。结果通过正交试验筛选的最优条件为包合时间6 h，搅拌强度70 rpm，包合温度70℃，辣椒碱与β-环糊精质量比为1：21，溶液 pH 值为11。在25、37、45℃条件下包合物中辣椒碱的溶解度极大值分别为0.32、0.60、1.08 mg·mL-1。结论辣椒碱与β-环糊精能形成稳定的包合物，制成包合物后辣椒碱的溶解度增加。
목적：제비랄초감-β-배호정포합물，고찰기용해도。방법채용공침정법제비포합물，용정교설계우화포합물형성적최가조건，채용상용해도법측정포합물적표관용해도화포합은정상수。결과통과정교시험사선적최우조건위포합시간6 h，교반강도70 rpm，포합온도70℃，랄초감여β-배호정질량비위1：21，용액 pH 치위11。재25、37、45℃조건하포합물중랄초감적용해도겁대치분별위0.32、0.60、1.08 mg·mL-1。결론랄초감여β-배호정능형성은정적포합물，제성포합물후랄초감적용해도증가。
Objective To prepare capsaicin-β-cyclodextrin inclusion complex (CAP-β-CD) and inspect their solu-bilities. Methods CAP-β-CD was prepared by the coprecipitation method and optimum formation conditions for preparation was selected by orthogonal design. The measurements of the apparent solubility and equilibrium constant were carried out by phase solubility diagram. Results The optimal conditions for forming CAP-β-CD complexes were 21:1 of capsaicin to cylcodextrin molar ratio, 70℃of temperature, 70 rpm of stirring strength, and 6 h of reaction duration at pH 11. The solubilities of capsaicin in inclusion complexes were the biggest at 25, 37, 45 ℃, which were 0.32, 0.60, 1.08 mg·mL -1, respectively. Conclusion By forming stable inclusion complex with β-CD, the solubility of capsaicin was increased.