CAJ | 학술논문

目的：比较活犀角与犀角的解热作用有无明显差异，判断活犀角是否可以作为犀角的代用品。方法采用细菌内毒素家兔致热模型，研究活犀牛角对家兔发热的预防作用；采用干酵母致大鼠发热模型，研究活犀牛角对发热大鼠的解热作用。结果活犀角50、100、200 mg·kg-1能明显预防细菌内毒素致热家兔的发热体温，活犀角220、440 mg·kg-1能明显降低干酵母引起的大鼠体温升高，相同剂量的犀角和活犀角比较，降温作用无明显差异。结论活犀角的解热作用与犀角相同，在解热作用方面可以作为犀角的代用品使用。
목적：비교활서각여서각적해열작용유무명현차이，판단활서각시부가이작위서각적대용품。방법채용세균내독소가토치열모형，연구활서우각대가토발열적예방작용；채용간효모치대서발열모형，연구활서우각대발열대서적해열작용。결과활서각50、100、200 mg·kg-1능명현예방세균내독소치열가토적발열체온，활서각220、440 mg·kg-1능명현강저간효모인기적대서체온승고，상동제량적서각화활서각비교，강온작용무명현차이。결론활서각적해열작용여서각상동，재해열작용방면가이작위서각적대용품사용。
Objective To observe the difference in antipyretic effects between living rhino horn and rhino horn by the comparative research method. Methods The antipyretic effect of the living rhino horn was evaluated in rabbit fever model by subcutaneous injection of bacterial endotoxin, and in rat fever model by subcutaneous injection of dried yeast. Results The living rhino horn of 50, 100 and 200 mg·kg -1 significantly reduced the temperature of fever rabbits. The living rhino horn of 220 and 440 mg·kg-1 significantly prevented the body temperature from rising in rats. There was no significant difference in antipyretic effects between the traditional rhino horn and the living rhino horn at the same dose. Conclusion The antipyretic effect of living rhino horn is equal to that of the traditional rhino horn, and the living rhino horn can be used as a substitute of rhino horn.