中国药物警戒
中國藥物警戒
중국약물경계
CHINESE JOURNAL OF PHARMACOVIGILANCE
2015年
3期
140-143
,共4页
赵俊茹%汪文玉%左付国%李小茜%胡冬裴
趙俊茹%汪文玉%左付國%李小茜%鬍鼕裴
조준여%왕문옥%좌부국%리소천%호동배
夏枯草%痤疮%唾液%白细胞介素 -1α%白细胞介素 -4%白细胞介素 -8%肿瘤坏死因子 -α
夏枯草%痤瘡%唾液%白細胞介素 -1α%白細胞介素 -4%白細胞介素 -8%腫瘤壞死因子 -α
하고초%좌창%타액%백세포개소 -1α%백세포개소 -4%백세포개소 -8%종류배사인자 -α
Prunella vulgaris L.%acne%saliva%IL-1α%IL-4%IL-8%TNF-α
目的：检测夏枯草对中、重度痤疮患者唾液中白细胞介素1α（interleukin-1α, IL-1α）、白细胞介素4（inter-leukin-4, IL-4）、白细胞介素8（interleukin-8, IL-8）和肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)表达的影响。方法对100例中、重度痤疮患者口服夏枯草水煎液治疗，其中Ⅱ级38例，Ⅲ级27例，Ⅳ级35例，每人每日15 g，连续1周。采集非刺激性全唾液，运用酶联免疫吸附法（enzyme-linked immunosorbent assay，ELISA）分别检测患者治疗前后及40名正常对照者唾液中 IL-1α、IL-4、IL-8和 TNF-α的表达水平。结果痤疮患者唾液中 IL-1α、IL-4、IL-8和 TNF-α水平较对照组有不同程度的升高，其变化程度均为Ⅳ级＞Ⅲ级＞Ⅱ级，治疗后 IL-1α、IL-4、IL-8和 TNF-α水平较治疗前明显降低。结论痤疮的发病与唾液中 IL-1α、IL-4、IL-8和 TNF-α水平的表达密切相关，说明免疫因素是导致痤疮发生发展的重要环节，夏枯草可能通过调节痤疮患者外周免疫因素起到治疗痤疮的作用。
目的：檢測夏枯草對中、重度痤瘡患者唾液中白細胞介素1α（interleukin-1α, IL-1α）、白細胞介素4（inter-leukin-4, IL-4）、白細胞介素8（interleukin-8, IL-8）和腫瘤壞死因子-α(tumor necrosis factor-α, TNF-α)錶達的影響。方法對100例中、重度痤瘡患者口服夏枯草水煎液治療，其中Ⅱ級38例，Ⅲ級27例，Ⅳ級35例，每人每日15 g，連續1週。採集非刺激性全唾液，運用酶聯免疫吸附法（enzyme-linked immunosorbent assay，ELISA）分彆檢測患者治療前後及40名正常對照者唾液中 IL-1α、IL-4、IL-8和 TNF-α的錶達水平。結果痤瘡患者唾液中 IL-1α、IL-4、IL-8和 TNF-α水平較對照組有不同程度的升高，其變化程度均為Ⅳ級＞Ⅲ級＞Ⅱ級，治療後 IL-1α、IL-4、IL-8和 TNF-α水平較治療前明顯降低。結論痤瘡的髮病與唾液中 IL-1α、IL-4、IL-8和 TNF-α水平的錶達密切相關，說明免疫因素是導緻痤瘡髮生髮展的重要環節，夏枯草可能通過調節痤瘡患者外週免疫因素起到治療痤瘡的作用。
목적：검측하고초대중、중도좌창환자타액중백세포개소1α（interleukin-1α, IL-1α）、백세포개소4（inter-leukin-4, IL-4）、백세포개소8（interleukin-8, IL-8）화종류배사인자-α(tumor necrosis factor-α, TNF-α)표체적영향。방법대100례중、중도좌창환자구복하고초수전액치료，기중Ⅱ급38례，Ⅲ급27례，Ⅳ급35례，매인매일15 g，련속1주。채집비자격성전타액，운용매련면역흡부법（enzyme-linked immunosorbent assay，ELISA）분별검측환자치료전후급40명정상대조자타액중 IL-1α、IL-4、IL-8화 TNF-α적표체수평。결과좌창환자타액중 IL-1α、IL-4、IL-8화 TNF-α수평교대조조유불동정도적승고，기변화정도균위Ⅳ급＞Ⅲ급＞Ⅱ급，치료후 IL-1α、IL-4、IL-8화 TNF-α수평교치료전명현강저。결론좌창적발병여타액중 IL-1α、IL-4、IL-8화 TNF-α수평적표체밀절상관，설명면역인소시도치좌창발생발전적중요배절，하고초가능통과조절좌창환자외주면역인소기도치료좌창적작용。
Objective To detect effects of Prunella vulgaris L. on expressions of IL-1α、IL-4、IL-8 and TNF-α in saliva of patients with acne. Methods 100 patients with severe acne were treated with water extract of Prunella vul-garis L. for a week, 15 g·d-1 each person, including 38Ⅱlevel patients, 27 Ⅲ level patients, 35 Ⅳ level patients. 40 cases of normal people were selected as control. The levels of IL-1α, IL-4, IL-8 and TNF-α were respectively measured before and after treatment by ELISA kits. Results Compared with the control group, the levels of IL-1α, IL-4, IL-8 and TNF-α had different degree of rise. The variability of the population were all Ⅳ level>Ⅲ level>Ⅱ level. The levels of IL-1α, IL-4, IL-8 and TNF-α were significantly decreased. Conclusion The onset of acne was closely related with the expression of IL-1α, IL-4, IL-8 and TNF-α in saliva, illustrating the immune factors played important roles in the onset and development of acne. Further study of the pathogenesis of acne immune mechanism has a guiding significance for clinical diagnosis and therapy, Prunella vulgaris L. may be effective for acne by adjusting peripheral immune factors in patlents with acne.
