CAJ | 학술논문

乙醛脱氢酶2(aldehyde dehydrogenase 2,ALDH2)是酒精代谢的关键酶,在酒精代谢产生的致癌物乙醛的催化过程中起着重要的作用,其基因多态性(尤其是rs671位点)与饮酒人群肿瘤的发生密切相关.本文重点就ALDH2基因rs671位点的多态性与饮酒人群肿瘤易感性的相关性这一热点研究作一综述.
을철탈경매2(aldehyde dehydrogenase 2,ALDH2)시주정대사적관건매,재주정대사산생적치암물을철적최화과정중기착중요적작용,기기인다태성(우기시rs671위점)여음주인군종류적발생밀절상관.본문중점취ALDH2기인rs671위점적다태성여음주인군종류역감성적상관성저일열점연구작일종술.
Aldehyde dehydrogenase 2 (ALDH2),as one of the most important alcohol metabolizing enzymes,plays a significant role in the detoxification process of acetaldehyde which is a main carcinogenic product of alcoholic metabolism.Alteration in its genotypes (particularly at the site of rs671) is closely associated with a variety of tumors in drinkers.Recent advance in the research of the association of the ALDH2 gene rs671 polymorphisms with cancer susceptibility in drinkers is reviewed.