中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
11期
3-5
,共3页
杨敏%李林瑞%孟燕妮%陈艳萍
楊敏%李林瑞%孟燕妮%陳豔萍
양민%리림서%맹연니%진염평
凝血酶敏感蛋白-1%CD36%支气管肺发育不良%ELISA
凝血酶敏感蛋白-1%CD36%支氣管肺髮育不良%ELISA
응혈매민감단백-1%CD36%지기관폐발육불량%ELISA
Thrombospodin-1%CD36%Bronchopulmonary dysplasia%ELISA
目的：探讨凝血酶敏感蛋白-1(TSP-1)及其受体CD36在支气管肺发育不良(BPD)患儿血清、支气管肺泡灌洗液中的表达及临床意义。方法：采用ELISA法检测45例BPD患儿与32例非BPD新生儿血清、支气管肺泡灌洗液的TSP-1及CD36表达水平并进行比较，同时对BPD患儿的TSP-1及CD36表达进行相关性分析。结果：BPD患儿血清、支气管肺泡灌洗液的TSP-1及CD36水平均高于正常儿童(P<0.05)；BPD患儿血清、支气管肺泡灌洗液的TSP-1与CD36表达均呈正相关性关系(P<0.05)。结论：TSP-1及其受体CD36可能参与了新生儿BPD的发病过程并起协同致病作用，具体机制有待进一步研究。
目的：探討凝血酶敏感蛋白-1(TSP-1)及其受體CD36在支氣管肺髮育不良(BPD)患兒血清、支氣管肺泡灌洗液中的錶達及臨床意義。方法：採用ELISA法檢測45例BPD患兒與32例非BPD新生兒血清、支氣管肺泡灌洗液的TSP-1及CD36錶達水平併進行比較，同時對BPD患兒的TSP-1及CD36錶達進行相關性分析。結果：BPD患兒血清、支氣管肺泡灌洗液的TSP-1及CD36水平均高于正常兒童(P<0.05)；BPD患兒血清、支氣管肺泡灌洗液的TSP-1與CD36錶達均呈正相關性關繫(P<0.05)。結論：TSP-1及其受體CD36可能參與瞭新生兒BPD的髮病過程併起協同緻病作用，具體機製有待進一步研究。
목적：탐토응혈매민감단백-1(TSP-1)급기수체CD36재지기관폐발육불량(BPD)환인혈청、지기관폐포관세액중적표체급림상의의。방법：채용ELISA법검측45례BPD환인여32례비BPD신생인혈청、지기관폐포관세액적TSP-1급CD36표체수평병진행비교，동시대BPD환인적TSP-1급CD36표체진행상관성분석。결과：BPD환인혈청、지기관폐포관세액적TSP-1급CD36수평균고우정상인동(P<0.05)；BPD환인혈청、지기관폐포관세액적TSP-1여CD36표체균정정상관성관계(P<0.05)。결론：TSP-1급기수체CD36가능삼여료신생인BPD적발병과정병기협동치병작용，구체궤제유대진일보연구。
Objective:To investigate the expression and clinical significance of thrombospodin-1 (TSP-1) and its receptor CD36 in bronchopulmonary dysplasia (BPD) children serum and bronchoalveolar lavage fluid.Method:The expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid of BPD children(n=45) and non-BPD neonatus(n=32) were detected by ELISA.Correlations of TSP-1 and CD36 levels and the comparisons between groups were analyzed respectively.Result:The expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid of BPD children were significantly higher than those of non-BPD neonates respectively(P<0.05).There was a positive correlation relationship between the expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid(P<0.05).Conclusion:TSP-1 and CD36 may play a role in the pathogenesis of neonatus BPD and act cooperatively through an unexplored mechanism,the specific mechanism needs further study.
