中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
11期
1-2,3
,共3页
晚期癌痛%吗啡%阿米替林%异丙嗪%止痛
晚期癌痛%嗎啡%阿米替林%異丙嗪%止痛
만기암통%마배%아미체림%이병진%지통
Advanced cancer pain%Morphine%Amitriptyline%Phenergan%Analgesia
目的：探讨吗啡和阿米替林、异丙嗪在三阶梯止痛中的作用。方法：选取笔者所在科室2012年6月-2013年6月收治的106例晚期癌症疼痛患者，根据用药情况将所有患者分为单用吗啡组(A组)35例、吗啡联合阿米替林组(B组)35例和吗啡联合用异丙嗪(C组)36例。三组患者治疗前与治疗后6周采用VAS评分对疼痛程度进行评价，采用SDS抑郁自评量表评分对抑郁状况进行评价，并比较三组患者的止痛疗效。结果：三组患者治疗后的VAS评分均明显低于治疗前，差异均有统计学意义(P<0.01)。A组治疗后的SDS评分较治疗前稍下降，但比较差异无统计学意义(P=0.04)，B组和C组治疗后的SDS评分均明显低于治疗前，差异均有统计学意义(P<0.01)。A组单用吗啡的止痛总有效率为51.4%，B组和C组的止痛总有效率分别为74.3%和83.3%，均明显高于A组，差异均有统计学意义(P<0.01)。结论：止痛药联合应用可减少吗啡的用量，能够提高患者生存质量，改善抑郁症状，较安全，值得临床推广。
目的：探討嗎啡和阿米替林、異丙嗪在三階梯止痛中的作用。方法：選取筆者所在科室2012年6月-2013年6月收治的106例晚期癌癥疼痛患者，根據用藥情況將所有患者分為單用嗎啡組(A組)35例、嗎啡聯閤阿米替林組(B組)35例和嗎啡聯閤用異丙嗪(C組)36例。三組患者治療前與治療後6週採用VAS評分對疼痛程度進行評價，採用SDS抑鬱自評量錶評分對抑鬱狀況進行評價，併比較三組患者的止痛療效。結果：三組患者治療後的VAS評分均明顯低于治療前，差異均有統計學意義(P<0.01)。A組治療後的SDS評分較治療前稍下降，但比較差異無統計學意義(P=0.04)，B組和C組治療後的SDS評分均明顯低于治療前，差異均有統計學意義(P<0.01)。A組單用嗎啡的止痛總有效率為51.4%，B組和C組的止痛總有效率分彆為74.3%和83.3%，均明顯高于A組，差異均有統計學意義(P<0.01)。結論：止痛藥聯閤應用可減少嗎啡的用量，能夠提高患者生存質量，改善抑鬱癥狀，較安全，值得臨床推廣。
목적：탐토마배화아미체림、이병진재삼계제지통중적작용。방법：선취필자소재과실2012년6월-2013년6월수치적106례만기암증동통환자，근거용약정황장소유환자분위단용마배조(A조)35례、마배연합아미체림조(B조)35례화마배연합용이병진(C조)36례。삼조환자치료전여치료후6주채용VAS평분대동통정도진행평개，채용SDS억욱자평량표평분대억욱상황진행평개，병비교삼조환자적지통료효。결과：삼조환자치료후적VAS평분균명현저우치료전，차이균유통계학의의(P<0.01)。A조치료후적SDS평분교치료전초하강，단비교차이무통계학의의(P=0.04)，B조화C조치료후적SDS평분균명현저우치료전，차이균유통계학의의(P<0.01)。A조단용마배적지통총유효솔위51.4%，B조화C조적지통총유효솔분별위74.3%화83.3%，균명현고우A조，차이균유통계학의의(P<0.01)。결론：지통약연합응용가감소마배적용량，능구제고환자생존질량，개선억욱증상，교안전，치득림상추엄。
Objective:To investigate the role of Morphine,Amitriptyline and Phenergan in tri-ladder analgesia.Method:According to drug administration,106 patients with advanced cancer pain in the department of our hospital from June 2012 to June 2013 were selected as research objects, they were divided into 3 groups:the group A(single use of Morphine),the group B(combined use of Morphine and Amitriptyline) and the group C(combined use of Morphine and Phenergan).The VAS score was used to evaluate the pain degree before treatment and after 6 weeks of treatment,VAS assessment was adopted to evaluate pain level among the three groups,the SDS self-rating Depression Scale was adopted to compare depression among different groups, the curative effect among the three groups were compared.Result:The VAS pain scores of the three groups patients after treatment were significantly lower than those of before treatment,the differences were statistically significant(P<0.01).The SDS score of the group A was decreased slightly compared with before treatment,there was no statistically significant difference(P=0.04),the SDS scores of the group B and the group C after treatment were lower than those of before treatment,the differences were statistically significant(P<0.01).The single Morphine analgesic total efficiency of the group A was 51.4%, the analgesic total effective of the group B and the group C were 74.3%and 83.3%respectively,which were significantly higher than the group A,the differences were statistically significant(P<0.01).Conclusion:Combined use of analgesic drugs can reduce the dosage of Morphine,improve the quality of life and alleviate the depression of advanced cancer patients,more safety,is worth clinical promotion.
