CAJ | 학술논문

卵巢恶性肿瘤是病死率最高的妇科疾病,严重威胁女性的健康.固有性免疫系统发挥重要免疫防御作用,作用的关键是对病原体的识别,这一识别主要是通过Toll样受体(TLRs)完成的.TLRs是近年免疫学研究的焦点,其不仅通过对病原微生物的病原相关分子模式的识别激活固有性免疫应答,还引起细胞因子的释放,上调共刺激分子的表达,为适应性免疫的启动提供必要的活化信号.因此,TLRs在很多疾病的发生和进展中起重要作用.阐明TLRs和固有免疫在卵巢恶性肿瘤中的作用可能会为研究者提供一个更好地了解这种疾病的分子机制.此外,利用TLRs的激动剂或拮抗剂有希望成为对抗卵巢恶性肿瘤的新的免疫治疗方法.
란소악성종류시병사솔최고적부과질병,엄중위협녀성적건강.고유성면역계통발휘중요면역방어작용,작용적관건시대병원체적식별,저일식별주요시통과Toll양수체(TLRs)완성적.TLRs시근년면역학연구적초점,기불부통과대병원미생물적병원상관분자모식적식별격활고유성면역응답,환인기세포인자적석방,상조공자격분자적표체,위괄응성면역적계동제공필요적활화신호.인차,TLRs재흔다질병적발생화진전중기중요작용.천명TLRs화고유면역재란소악성종류중적작용가능회위연구자제공일개경호지료해저충질병적분자궤제.차외,이용TLRs적격동제혹길항제유희망성위대항란소악성종류적신적면역치료방법.
The mortality of ovary cancer is the highest in gynecologic cancers.Innate immune system plays an important role in immune defense,particularly in the recognition of pathogens,which is mainly through Toll-like receptors(TLRs).TLRs have been hot research molecules.The discovery of TLRs has changed our understanding about the mechanism of diseases.The activation of TLRs leads to release of cytokines and chemokines.TLRs also activate adaptive immunity.TLRs play an important role in ovary cancer development.The agonists and antagonists of TLRs might become novel therapeutic agents for ovary cancer.