CAJ | 학술논문

巨噬细胞在调控炎症及免疫反应,维持免疫稳态中发挥关键的作用.不同微环境条件下,巨噬细胞功能出现异质性.其可以极化为经典活化(M1)或替代活化(M2)两种不同的极化类型,分别发挥促炎或抑炎的功能.众所周知,许多调控分子参与了巨噬细胞的极化调控过程.在众多的极化调控分子中,信号转导及转录激活因子(Stats)家族是一类最主要的调控分子.Stats家族有7个成员,即Stat1、Stat2、Stat3、Stat4、Stat5a、Stat5b和Stat6.它们结构相似,但功能不同.目前已经明确,Stats分子在机体炎症应答中发挥重要的作用,调控着巨噬细胞的极化进程.
거서세포재조공염증급면역반응,유지면역은태중발휘관건적작용.불동미배경조건하,거서세포공능출현이질성.기가이겁화위경전활화(M1)혹체대활화(M2)량충불동적겁화류형,분별발휘촉염혹억염적공능.음소주지,허다조공분자삼여료거서세포적겁화조공과정.재음다적겁화조공분자중,신호전도급전록격활인자(Stats)가족시일류최주요적조공분자.Stats가족유7개성원,즉Stat1、Stat2、Stat3、Stat4、Stat5a、Stat5b화Stat6.타문결구상사,단공능불동.목전이경명학,Stats분자재궤체염증응답중발휘중요적작용,조공착거서세포적겁화진정.
Macrophages play a key role in the regulation of inflammation and immune responses,and in the maintenance of immune homeostasis.Under different microenvironments,macrophages function heterogeneously.They can alter themselves into two different types of polarization,classically-activated (M1) and alternatively-activated (M2),in order to display pro-inflammatory or anti-inflammatory functions.Many regulatory molecules are involved in this progress of macrophage polarization.Among these regulatory molecules,signal transducers and activators of transcription (Stats) family is of the most important.Stats family has seven members with similar structures and different functions,called Stat1,Star2,Stat3,Stat4,Stat5a,Stat5b,and Star6.It is clear now that Stats family plays an important role in inflammatory responses,and in the process of macrophage polarization.