国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2015年
1期
31-34
,共4页
Rac1%免疫调节%疾病%肿瘤
Rac1%免疫調節%疾病%腫瘤
Rac1%면역조절%질병%종류
Rac1%Immune regulation%Disease%The tumor
Rho蛋白是一种具有三磷酸鸟苷(GTP)酶活性的小分子蛋白,Rac1是其家族成员之一,是细胞内重要的信号转导分子,在多种细胞的基本功能中发挥分子开关作用.它一方面可参与免疫调节及细胞周期、细胞骨架重排、细胞运动与转移的调节等,另一方面在许多疾病如哮喘、房颤、感染性疾病、肿瘤等中异常表达,且与肿瘤的侵袭和转移密切相关,有可能成为判断肿瘤发展和预后的新指标.
Rho蛋白是一種具有三燐痠鳥苷(GTP)酶活性的小分子蛋白,Rac1是其傢族成員之一,是細胞內重要的信號轉導分子,在多種細胞的基本功能中髮揮分子開關作用.它一方麵可參與免疫調節及細胞週期、細胞骨架重排、細胞運動與轉移的調節等,另一方麵在許多疾病如哮喘、房顫、感染性疾病、腫瘤等中異常錶達,且與腫瘤的侵襲和轉移密切相關,有可能成為判斷腫瘤髮展和預後的新指標.
Rho단백시일충구유삼린산조감(GTP)매활성적소분자단백,Rac1시기가족성원지일,시세포내중요적신호전도분자,재다충세포적기본공능중발휘분자개관작용.타일방면가삼여면역조절급세포주기、세포골가중배、세포운동여전이적조절등,령일방면재허다질병여효천、방전、감염성질병、종류등중이상표체,차여종류적침습화전이밀절상관,유가능성위판단종류발전화예후적신지표.
Rho is a family of small proteins the activity of guanosine triphosphate(GTP) ase.Rac1 is a member of the Rho family.Rac1 is an important signal transduction molecule and it acts as a molecular switch in the basic functions of cells.Rac1 participates in immune regulation,cell cycle,cytoskeleton rearrangement,cell movement.Abnormal expression of Rac1 has been found in many diseases such as asthma,atrial fibrillation,infectious disease and tumor.Moreover,it is closely related to tumor invasion and metastasis.Rac1 may become the new marker for the evalnation of tumor development and prognosis.
