CAJ | 학술논문

目的检测急性冠脉综合征(ACS)患者外周血中CD4+ CD28-T细胞与IL-6和C-反应蛋白(CRP)相关性.方法选取43例ACS患者,40例稳定性心绞痛(SAP),选取40例健康人作为正常对照.采用流式细胞分析仪测定CD4+ CD28-T细胞;IL-6和CRP水平分别采用ELISA法和特种蛋白分析仪进行测定.结果 ACS组患者的CD4+ CD28-T细胞数量和IL-6和CRP水平均显著高于SAP组(P＜0.001)或正常对照组(P＜0.001),而且ACS患者CD4+ CD28-T细胞与IL-6(r=0.79,P＜0.001)和CRP(r=0.50,P＜0.001)具有相关性.结论 ACS患者CD4+ CD28-T细胞数量的增高与IL-6和CRP高度相关,可能参与冠心病的病程进展.
목적 검측급성관맥종합정(ACS)환자외주혈중CD4+ CD28-T세포여IL-6화C-반응단백(CRP)상관성.방법 선취43례ACS환자,40례은정성심교통(SAP),선취40례건강인작위정상대조.채용류식세포분석의측정CD4+ CD28-T세포;IL-6화CRP수평분별채용ELISA법화특충단백분석의진행측정.결과 ACS조환자적CD4+ CD28-T세포수량화IL-6화CRP수평균현저고우SAP조(P＜0.001)혹정상대조조(P＜0.001),이차ACS환자CD4+ CD28-T세포여IL-6(r=0.79,P＜0.001)화CRP(r=0.50,P＜0.001)구유상관성.결론 ACS환자CD4+ CD28-T세포수량적증고여IL-6화CRP고도상관,가능삼여관심병적병정진전.
Objective To evaluate the correlation of CD4 + CD28T cells with interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with acute coronary syndromes (ACS).Method 43 patients with acute coronary syndromes,40 patients with stable angina pectoris(SAP) and 40 healthy subjects were studied.CD4 + CD28-T cells were investigated by flow cytometric analysis,and IL-6 and CRP were determined by ELISA and special protein analyzer respectively.Result:The results demonstrated that the frequency of CD4 + CD28-T cells and levels of IL-6 and CRP in patients with ACS were higher (P ＜ 0.01) than those in patients with SAP and in controls,and the frequency of CD4 + CD28T cells were correlated with IL-6 (r =0.79,P ＜ 0.001) and CRP(r =0.50,P ＜ 0.001).Conclusion The expansion of CD4 + CD28-T cells in ACS was significantly correlated with IL-6 and CRP,and then participates in the process of ACS.