临床内科杂志
臨床內科雜誌
림상내과잡지
JOURNAL OF CLINICAL INTERNAL MEDICINE
2015年
3期
178-180
,共3页
李方江%王晓元%杜美玲%李清
李方江%王曉元%杜美玲%李清
리방강%왕효원%두미령%리청
急性冠状动脉综合征%皮冠状动脉介入治疗%白细胞介素-6 受体%金属肽酶含血小板反应蛋白基元-1%氧化型低密度脂蛋白
急性冠狀動脈綜閤徵%皮冠狀動脈介入治療%白細胞介素-6 受體%金屬肽酶含血小闆反應蛋白基元-1%氧化型低密度脂蛋白
급성관상동맥종합정%피관상동맥개입치료%백세포개소-6 수체%금속태매함혈소판반응단백기원-1%양화형저밀도지단백
Acute coronary syndrome%Percutaneous coronary intervention%Interleukin 6 receptor%Adisintegrin and metalloprotease with thrombospongdin type 1 motifs%Oxidized low density lipoprotein
目的：探讨急性冠状动脉综合征（ACS）经皮冠状动脉介入治疗（PCI）术前与术后患者炎性标记物：白细胞介素-6受体（IL-6R）和金属肽酶含血小板反应蛋白基元-1（ADAMTS-1）及氧化型低密度脂蛋白（ox-LDL）水平的变化及意义。方法选取 ACS 患者149例，其中急诊 PCI 急性心肌梗死（AMI）39例，PCI 不稳定型心绞痛（UA）42例；非 PCI 患者 AMI 32例，UA 36例。冠状动脉造影检查证实冠脉无狭窄对照组56例。所有研究对象入院时采静脉血，ACS 入院12小时后再次采静脉血，应用酶联免疫吸附试验（ELISA）法检测外周血 IL-6R、ADAMTS-1及 ox-LDL 水平。结果入院时 PCI AMI 组、PCI UA 组、AMI 组及 UA 组 IL-6R、ADAMTS-1及 ox-LDL 血清水平均高于对照组，差异有统计学意义（P ＜0．05）。入院时 PCI AMI 组及 AMI 组 ox-LDL 血清水平高于 PCI UA组、UA 组，差异有统计学意义（P ＜0．05）。入院12小时后 PCI AMI 组、PCI UA 组 IL-6R、ADAMTS-1水平均较入院时升高，差异有统计学意义（P ＜0．05）；而入院12小时后 AMI 组、UA 组 IL-6R、ADAMTS-1水平较入院时比较差异无统计学意义（P ＞0．05）。结论IL-6R、ADAMTS-1是 ACS 炎症反应的重要标志，ACS 经皮冠状动脉介入治疗术后炎症反应增加。
目的：探討急性冠狀動脈綜閤徵（ACS）經皮冠狀動脈介入治療（PCI）術前與術後患者炎性標記物：白細胞介素-6受體（IL-6R）和金屬肽酶含血小闆反應蛋白基元-1（ADAMTS-1）及氧化型低密度脂蛋白（ox-LDL）水平的變化及意義。方法選取 ACS 患者149例，其中急診 PCI 急性心肌梗死（AMI）39例，PCI 不穩定型心絞痛（UA）42例；非 PCI 患者 AMI 32例，UA 36例。冠狀動脈造影檢查證實冠脈無狹窄對照組56例。所有研究對象入院時採靜脈血，ACS 入院12小時後再次採靜脈血，應用酶聯免疫吸附試驗（ELISA）法檢測外週血 IL-6R、ADAMTS-1及 ox-LDL 水平。結果入院時 PCI AMI 組、PCI UA 組、AMI 組及 UA 組 IL-6R、ADAMTS-1及 ox-LDL 血清水平均高于對照組，差異有統計學意義（P ＜0．05）。入院時 PCI AMI 組及 AMI 組 ox-LDL 血清水平高于 PCI UA組、UA 組，差異有統計學意義（P ＜0．05）。入院12小時後 PCI AMI 組、PCI UA 組 IL-6R、ADAMTS-1水平均較入院時升高，差異有統計學意義（P ＜0．05）；而入院12小時後 AMI 組、UA 組 IL-6R、ADAMTS-1水平較入院時比較差異無統計學意義（P ＞0．05）。結論IL-6R、ADAMTS-1是 ACS 炎癥反應的重要標誌，ACS 經皮冠狀動脈介入治療術後炎癥反應增加。
목적：탐토급성관상동맥종합정（ACS）경피관상동맥개입치료（PCI）술전여술후환자염성표기물：백세포개소-6수체（IL-6R）화금속태매함혈소판반응단백기원-1（ADAMTS-1）급양화형저밀도지단백（ox-LDL）수평적변화급의의。방법선취 ACS 환자149례，기중급진 PCI 급성심기경사（AMI）39례，PCI 불은정형심교통（UA）42례；비 PCI 환자 AMI 32례，UA 36례。관상동맥조영검사증실관맥무협착대조조56례。소유연구대상입원시채정맥혈，ACS 입원12소시후재차채정맥혈，응용매련면역흡부시험（ELISA）법검측외주혈 IL-6R、ADAMTS-1급 ox-LDL 수평。결과입원시 PCI AMI 조、PCI UA 조、AMI 조급 UA 조 IL-6R、ADAMTS-1급 ox-LDL 혈청수평균고우대조조，차이유통계학의의（P ＜0．05）。입원시 PCI AMI 조급 AMI 조 ox-LDL 혈청수평고우 PCI UA조、UA 조，차이유통계학의의（P ＜0．05）。입원12소시후 PCI AMI 조、PCI UA 조 IL-6R、ADAMTS-1수평균교입원시승고，차이유통계학의의（P ＜0．05）；이입원12소시후 AMI 조、UA 조 IL-6R、ADAMTS-1수평교입원시비교차이무통계학의의（P ＞0．05）。결론IL-6R、ADAMTS-1시 ACS 염증반응적중요표지，ACS 경피관상동맥개입치료술후염증반응증가。
Objective To investigate the changes and significance of inflammatory markers:interleu-kin 6 receptor(IL-6R),adisintegrin and metalloprotease with thrombospongdin type 1 motifs(ADAMTS-1), oxidized low density lipoprotein(ox-LDL)preoperative and postoperative of percutaneous coronary inter-vention(PCI)in patients of acute coronary syndrome(ACS).Methods 149 ACS patients were admitted, including 39 cases of acute myocardial infarction(AMI)and 42 unstable angina (UA)patients underwent PCI,32 cases of AMI and 36 UA patients without PCI.56 cases with no coronary artery stenosis were selected as a control group.Venous blood were collected at the time of admission,and will be collected again after 12 h in the ACS group,then detected the levels of IL-6R,ADAMTS-1 and ox-LDL of all the patients.Results The serum IL-6R,ADAMTS-1 and ox-LDL levels of group PCI-AMI,PCI-UA, no-PCI-AMI no-PCI-UA group were significantly higher than that of normal control group,the difference was statistically significant(P <0.05).The serum ox-LDL level of group PCI-AMI and no-PCI-AMI was significantly higher than that of PCI-UA and no-PCI-UA group(P <0.05);The serum IL-6R,ADAMTS-1 in group PCI-AMI and PCI-UA after 12 h increased compared with preoperative,the difference was statis-tically significant(P <0.05).The serum IL-6R,ADAMTS-1 after 12h had no statistical difference com-pared with the time of admission in group no-PCI-AMI and no-PCI-UA(P >0.05).Conclusion IL-6R and ADAMTS-1 are important symbols of inflammatory and the inflammatory levels increase after PCI in patients of ACS.
