CAJ | 학술논문

目的：探讨乙醛脱氢酶2（ALDH2）基因 rs671多态性在新疆地区汉族人群原发性高血压（EH）发病中的作用。方法应用 Taqman 技术检测了474例汉族 EH 患者和358例正常血压者 ALDH2基因 rs671多态性。结果在男性人群中，饮酒组 rs671的 GA ＋AA 基因型频率和 A 等位基因频率均明显低于不饮酒组（P ＜0．01）；EH 组 rs671的 GA ＋AA 基因型频率和 A 等位基因频率均明显低于对照组（P ＜0．01）。而在女性人群中，EH 组和对照组 rs671的 3 种基因型频率和等位基因频率的分布差异无统计学意义（P ＞0．05）。非条件 Logistic 回归分析校正年龄、体重指数、糖尿病史、饮酒史等影响因素后，在男性人群中 rs671的 GA ＋AA 基因型者患 EH 的风险低于 GG基因型者（OR ＝0．656，95％CI：0．448～0．962，P ＜0．05），GA ＋AA 基因型者收缩压水平明显低于GG 型者（P ＜0．05）。而在男性不饮酒者和女性人群中，GA ＋AA 基因型者和 GG 基因型者血压水平比较差异无统计学意义。结论ALDH2基因 rs671多态性可能和新疆汉族男性人群 EH 的发生相关，rs671的 GA ＋AA 基因型可能是汉族男性人群 EH 的一个保护因素。
목적：탐토을철탈경매2（ALDH2）기인 rs671다태성재신강지구한족인군원발성고혈압（EH）발병중적작용。방법응용 Taqman 기술검측료474례한족 EH 환자화358례정상혈압자 ALDH2기인 rs671다태성。결과재남성인군중，음주조 rs671적 GA ＋AA 기인형빈솔화 A 등위기인빈솔균명현저우불음주조（P ＜0．01）；EH 조 rs671적 GA ＋AA 기인형빈솔화 A 등위기인빈솔균명현저우대조조（P ＜0．01）。이재녀성인군중，EH 조화대조조 rs671적 3 충기인형빈솔화등위기인빈솔적분포차이무통계학의의（P ＞0．05）。비조건 Logistic 회귀분석교정년령、체중지수、당뇨병사、음주사등영향인소후，재남성인군중 rs671적 GA ＋AA 기인형자환 EH 적풍험저우 GG기인형자（OR ＝0．656，95％CI：0．448～0．962，P ＜0．05），GA ＋AA 기인형자수축압수평명현저우GG 형자（P ＜0．05）。이재남성불음주자화녀성인군중，GA ＋AA 기인형자화 GG 기인형자혈압수평비교차이무통계학의의。결론ALDH2기인 rs671다태성가능화신강한족남성인군 EH 적발생상관，rs671적 GA ＋AA 기인형가능시한족남성인군 EH 적일개보호인소。
[Abstract ] Objective To investigate the relationship between acetaldehyde dehydrogenase (ALDH)2 gene rs671 polymorphism and essential hypertension in a Han population in Xinjiang.Methods Taqman assay was performed to screen the polymorphism of ALDH2 gene rs671 in 474 EH patients and 358 normotensives.Results In males,the frequency of GA +AA genotype and A allele of rs671 was significant-ly lower in drinkers than that in non-drinkers(all P <0.01).Among males,the frequency of GA +AA geno-type and A allele of rs671 was significantly lower in patients with EH than in controls(P <0.01).Among females,there was no significant difference in the distribution of genotypes and allele of rs671 between EH group and controls group(P >0.05).Logistic regression analysis adjusted for confounding factors inclu-ding drinking for men showed that carriers of GA +AA genotype had an decreased risk of EH,compared to GG genotype(OR =0.656,95%CI:0.448-0.962,P <0.05).In male drinkers,the systolic blood pressure was significantly lower in subjects with GA +AA genotype than those with GG genotype (P <0.05).But this association was not observed in male non-drinkers and females.Conclusion For Han males,ALDH2 gene rs671 polymorphism was associated with the development of EH,while GA +AA genotype might be an influencing protective factor on EH.