国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2015年
1期
89-92
,共4页
NKp30受体%自然杀伤细胞%免疫逃逸%免疫监视
NKp30受體%自然殺傷細胞%免疫逃逸%免疫鑑視
NKp30수체%자연살상세포%면역도일%면역감시
NKp30%Natural killer cells%Immune evasion%Immunologic surveillance
自然杀伤(NK)细胞无需预先致敏即可快速杀伤靶细胞,是机体发挥抗肿瘤免疫和抗感染免疫的重要执行者.NK细胞的活化与否取决于细胞表面活化性受体和抑制性受体信号的平衡.NKp30是NK细胞表面的一种重要的活化性受体,可接收相应配体如BAG-6、B7-H6等分子信号进而激活NK细胞,发挥抗肿瘤和抗感染免疫作用.同时NKp30也是肿瘤细胞和病原体发生免疫逃逸的重要靶点,可通过多种机制逃逸NK细胞杀伤.此外,NKp30还参与了NK细胞和树突状细胞(DCs)间的双向免疫调节.
自然殺傷(NK)細胞無需預先緻敏即可快速殺傷靶細胞,是機體髮揮抗腫瘤免疫和抗感染免疫的重要執行者.NK細胞的活化與否取決于細胞錶麵活化性受體和抑製性受體信號的平衡.NKp30是NK細胞錶麵的一種重要的活化性受體,可接收相應配體如BAG-6、B7-H6等分子信號進而激活NK細胞,髮揮抗腫瘤和抗感染免疫作用.同時NKp30也是腫瘤細胞和病原體髮生免疫逃逸的重要靶點,可通過多種機製逃逸NK細胞殺傷.此外,NKp30還參與瞭NK細胞和樹突狀細胞(DCs)間的雙嚮免疫調節.
자연살상(NK)세포무수예선치민즉가쾌속살상파세포,시궤체발휘항종류면역화항감염면역적중요집행자.NK세포적활화여부취결우세포표면활화성수체화억제성수체신호적평형.NKp30시NK세포표면적일충중요적활화성수체,가접수상응배체여BAG-6、B7-H6등분자신호진이격활NK세포,발휘항종류화항감염면역작용.동시NKp30야시종류세포화병원체발생면역도일적중요파점,가통과다충궤제도일NK세포살상.차외,NKp30환삼여료NK세포화수돌상세포(DCs)간적쌍향면역조절.
Natural killer (NK) cells are central players in the human immune system.They can immediately eliminate malignantly transformed or infected cells without the need for prior antigen stimulation.The activation of NK cells depends on the balance of activating and inhibitory signals.NKp30 is an activating receptor expressed by NK cells,which triggers cytolytic activity against target cells through binding with the corresponding ligand,such as BAG-6,B7-H6.NKp30 also involves in tumor and pathogen immune evasion strategies through multiple mechanisms.Moreover,NKp30 plays a key role in NK-DC cross talk and directs both DC's maturation and NK's activation.
