CAJ | 학술논문

自噬是指细胞通过双层膜结构包裹胞浆物质运输至溶酶体进行消化降解和循环利用的过程,环境压力(如饥饿、缺氧、氧化应激、某些有害物质刺激等)可使其活化.动脉粥样硬化斑块破裂导致血栓形成是急性冠脉综合征发生的主要病理学基础,其中巨噬细胞是影响斑块稳定性的主要细胞.新近研究发现,基础水平的巨噬细胞自噬有利于预防动脉粥样硬化(AS)的形成、发展并维持斑块稳定,而自噬过程缺陷或不足则不利于斑块稳定.近年来,巨噬细胞自噬对AS斑块的影响受到了学术界的广泛关注,深入探讨其中的调节机制及作用效应,将为动脉粥样硬化的防治提供新的策略和靶点.
자서시지세포통과쌍층막결구포과포장물질운수지용매체진행소화강해화순배이용적과정,배경압력(여기아、결양、양화응격、모사유해물질자격등)가사기활화.동맥죽양경화반괴파렬도치혈전형성시급성관맥종합정발생적주요병이학기출,기중거서세포시영향반괴은정성적주요세포.신근연구발현,기출수평적거서세포자서유리우예방동맥죽양경화(AS)적형성、발전병유지반괴은정,이자서과정결함혹불족칙불리우반괴은정.근년래,거서세포자서대AS반괴적영향수도료학술계적엄범관주,심입탐토기중적조절궤제급작용효응,장위동맥죽양경화적방치제공신적책략화파점.
Autophagy is a process which delivers cytoplasmic contents sequestrated by double-membraned structures to the lysosome for degradation and recycling.It can be activated under pressure such as starvation,hypoxia,oxidative stress and harmful substances.Atherosclerotic plaque rupture and subsequent thrombosis formation are the main pathological basis leading to acute cardiovascular event.Macrophage is the main cell that influences the stability of the plaque.Receat investigation has demonstrated that basal levels of macrophage autophagy play a critical protective role in preventing the formation,progression and destabilization of atherosclerotic lesions,while dysfunctional autophagy is proatherogenic.The influence of macrophage autophagy on the stability of atherosclerotic lesions has been gaining widespread attention in recent years.Further investigation on the mechanism and effect of macrophage autophagy may provide new targets for the prevention and treatment of atherosclerosis.