中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2015年
4期
759-763
,共5页
低密度脂蛋白相关受体1%凝血因子Ⅷ%胞吞%信号通路
低密度脂蛋白相關受體1%凝血因子Ⅷ%胞吞%信號通路
저밀도지단백상관수체1%응혈인자Ⅷ%포탄%신호통로
Low-density lipoprotein receptor-related protein-1%Goàgulàtion factor Ⅷ%Endocytosis%Signalpathway
Low-density lipoprotein receptor-related protein-1 (LRP-1) is a transmembrane receptor protein locatedon the plasma membrane of the cells and involved in receptor-mediated endocytosis.LRP-1 binds to distinct ligandsthat are structurally and functionally unrelated, which makes it not only mediates endocytosis, but also regulates cell surfaceproteolytic activity and specific intracellular signaling pathways related to multiple links in the process of developmentof atherosclerosis.Moreover, LRP-1 plays an important role in maintaining vascular stability.This review focuses on theprogress in LRP-1-regulated vascular integrity, and provides new insights to the target of the blood vessel diseases.
