CAJ | 학술논문

神经胶质瘤是颅内最常见的肿瘤，尤其是恶性胶质瘤，具有高复发率和致死率的特点。因其侵袭性生长，目前采取的手术联合放化疗的综合治疗方案疗效欠佳。如何靶向显像和治疗胶质瘤成为研究的重点。近年来，大量研究表明，作为氯毒素的类似物，东亚钳蝎氯毒素能特异性地结合神经胶质瘤细胞表达的氯离子通道和基质金属蛋白酶2，从而抑制胶质瘤细胞的侵润生长和迁移。以东亚钳蝎氯毒素为配体的生物结合物在胶质瘤靶向显像和治疗中的研究越来越多。笔者将全面介绍东亚钳蝎氯毒素的来源、化学结构、作用机制及其在胶质瘤靶向显像与治疗中的应用研究进展，并总结其优势及在未来研究中所面临的挑战。
신경효질류시로내최상견적종류，우기시악성효질류，구유고복발솔화치사솔적특점。인기침습성생장，목전채취적수술연합방화료적종합치료방안료효흠가。여하파향현상화치료효질류성위연구적중점。근년래，대량연구표명，작위록독소적유사물，동아겸갈록독소능특이성지결합신경효질류세포표체적록리자통도화기질금속단백매2，종이억제효질류세포적침윤생장화천이。이동아겸갈록독소위배체적생물결합물재효질류파향현상화치료중적연구월래월다。필자장전면개소동아겸갈록독소적래원、화학결구、작용궤제급기재효질류파향현상여치료중적응용연구진전，병총결기우세급재미래연구중소면림적도전。
Gliomas, especially malignant gliomas, are the most common primary brain tumors associated with high recurrence rate and significant mortality. The combination of surgery and radio-chemotherapy is the best treatment for them nowadays. However, due to their biological characteristics of invasive growth, they do not respond well to traditional therapy. How to target the tumor in situ, and inhibit tumor cell proliferation and invasion is the key for study. In recent years, many studies have demonstrated that Buthus martensii Karsch chlorotoxin(BmK CT), an important chlorotoxin-like peptide, specifically inhibited glioma cells growth and metastasis as a blocker of the chloride ion channel and matrix metallopro-teinase-2 ( MMP-2 ) . The bioconjugates of BmK CT with other molecules have played an increasing role in targeted imaging and treatment of gliomas. In this review, its source, chemical structure and mechanisms will be provided. Besides, advantages and challenges in the use of BmK CT as a specific agent for imaging and theranostic applications in gliomas will be addressed.