岭南急诊医学杂志
嶺南急診醫學雜誌
령남급진의학잡지
LINGNAN JOURNAL OF EMERGENCY MEDICINE
2015年
1期
11-12,19
,共3页
盐酸曲美他嗪%阿托伐他汀钙%原发性高血压%内皮功能%临床效果
鹽痠麯美他嗪%阿託伐他汀鈣%原髮性高血壓%內皮功能%臨床效果
염산곡미타진%아탁벌타정개%원발성고혈압%내피공능%림상효과
trimetazidine hydrochloride%atorvastatincalcium%primary hypertension%endothelial function%clinical effect
目的：探讨盐酸曲美他嗪联合阿托伐他汀钙佐治原发性高血压的临床效果及对其内皮功能的影响。方法：将2011年10月－2014年7月我院收治的126例原发性高血压患者随机分为研究组和对照组各63例，对照组采取降压加阿托伐他汀钙治疗，研究组在对照组基础上加用盐酸曲美他嗪治疗。比较两组治疗前、后内皮素－1（ET－1）、一氧化氮（NO）、高敏C 反应蛋白（hs－CRP）、血压和血脂情况。结果：治疗4周后，研究组ET－1、hs－CRP 分别为（62．5±6．4）ng／L、（2．1±1．2）mg／L，均低于对照组的（64．8±6．4）ng／L、（2．6±1．4）mg／L；研究组NO 明显高于对照组（P ＜0．05）；治疗后两组血压均较治疗前明显下降，且研究组改善程度优于对照组（P＜0．05）；两组TC、LDL－C 均较治疗前明显下降，但无明显差异（P ＞0．05）。结论：盐酸曲美他嗪联合阿托伐他汀钙佐治原发性高血压效果确切，可明显改善内皮功能，值得临床推广应用。
目的：探討鹽痠麯美他嗪聯閤阿託伐他汀鈣佐治原髮性高血壓的臨床效果及對其內皮功能的影響。方法：將2011年10月－2014年7月我院收治的126例原髮性高血壓患者隨機分為研究組和對照組各63例，對照組採取降壓加阿託伐他汀鈣治療，研究組在對照組基礎上加用鹽痠麯美他嗪治療。比較兩組治療前、後內皮素－1（ET－1）、一氧化氮（NO）、高敏C 反應蛋白（hs－CRP）、血壓和血脂情況。結果：治療4週後，研究組ET－1、hs－CRP 分彆為（62．5±6．4）ng／L、（2．1±1．2）mg／L，均低于對照組的（64．8±6．4）ng／L、（2．6±1．4）mg／L；研究組NO 明顯高于對照組（P ＜0．05）；治療後兩組血壓均較治療前明顯下降，且研究組改善程度優于對照組（P＜0．05）；兩組TC、LDL－C 均較治療前明顯下降，但無明顯差異（P ＞0．05）。結論：鹽痠麯美他嗪聯閤阿託伐他汀鈣佐治原髮性高血壓效果確切，可明顯改善內皮功能，值得臨床推廣應用。
목적：탐토염산곡미타진연합아탁벌타정개좌치원발성고혈압적림상효과급대기내피공능적영향。방법：장2011년10월－2014년7월아원수치적126례원발성고혈압환자수궤분위연구조화대조조각63례，대조조채취강압가아탁벌타정개치료，연구조재대조조기출상가용염산곡미타진치료。비교량조치료전、후내피소－1（ET－1）、일양화담（NO）、고민C 반응단백（hs－CRP）、혈압화혈지정황。결과：치료4주후，연구조ET－1、hs－CRP 분별위（62．5±6．4）ng／L、（2．1±1．2）mg／L，균저우대조조적（64．8±6．4）ng／L、（2．6±1．4）mg／L；연구조NO 명현고우대조조（P ＜0．05）；치료후량조혈압균교치료전명현하강，차연구조개선정도우우대조조（P＜0．05）；량조TC、LDL－C 균교치료전명현하강，단무명현차이（P ＞0．05）。결론：염산곡미타진연합아탁벌타정개좌치원발성고혈압효과학절，가명현개선내피공능，치득림상추엄응용。
Objective:To explore the endothelial? function effect of trimetazidine hydrochloride combined with atorvastatin calcium adjunctive treatment for patients with primary hypertension. Methods: 126 patients with primary hypertension were randomly divided into research group(n=63) and control group(n=63).Control group was treated by atorvastatin calcium based on foundation decompression treatment ,while research group was treated by trimetazidine hydrochloride based on foundation of control group. The endothelin-1 (ET-1),nitric oxide (NO),high-sensitivity C-reactive protein (hs-CRP), blood pressure and lipid profile before and after treatment were compared between the two groups. Results:After four weeks of treatment,ET-1 and hs-CRP in research group were respectively (62.5±6.4) ng/L and (2.1±1.2) mg/L,which were lower than (64.8±6.4) ng/L and (2.6±1.4) mg/L in control group (P < 0.05). NO in research group was higher than that in control group (P < 0.05).After treatment,SBP and DBP decreased,the improvement degree in research group were better than those in control group (P < 0.05).TC and LDL-C were lower than those in before,but there were no significant differences between the two groups (P > 0.05). Conclusion:Trimetazidine hydrochloride combined with atorvastatin? calcium has exact effect for patients with primary hypertension based on foundation decompression treatment. It can improve endothelial? function effectively and is worthy of widely used.
