国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2015年
1期
11-15
,共5页
孙海荣%李振光%鞠晓华%王晶%张金彪
孫海榮%李振光%鞠曉華%王晶%張金彪
손해영%리진광%국효화%왕정%장금표
脑出血%卒中%脑缺血%胱抑素C%磁共振成像%危险因素
腦齣血%卒中%腦缺血%胱抑素C%磁共振成像%危險因素
뇌출혈%졸중%뇌결혈%광억소C%자공진성상%위험인소
Cerebral Hemorrhage%Stroke%Brain Ischemia%Cystatin C%Magnetic Resonance Imaging%Risk Factors
目的 探讨急性脑梗死患者血清胱抑素C(cystatin C,CysC)水平与脑微出血(cerebral microbleeds,CMBs)的相关性.方法 纳入急性缺血性卒中患者,应用磁敏感加权成像确定CMBs的存在,应用颗粒增强免疫比浊法测定血清CysC水平.结果 共纳入485例急性缺血性卒中患者,其中151例存在CMBs(31.1％).CMBs组血清CysC水平显著高于非CMBs组[(1.24±0.13)mg/L对(1.02±0.11) mg/L;=4.261,P＜0.001].多变量logistic回归分析显示,血清CysC水平增高是急性缺血性卒中患者存在CMBs的独立危险因素(每增高1个标准差优势比4.063,95％可信区间2.142～8.127;p＜0.001);多重线性回归分析显示,校正其他混杂因素后,急性缺血性卒中患者CMBs数量随着血清CysC水平的升高而增多(r2=0.361,P=0.017).结论 在急性缺血性卒中患者中,血清CysC水平与CMBs独立相关,且CMBs数量随着血清CysC水平的升高而增多.
目的 探討急性腦梗死患者血清胱抑素C(cystatin C,CysC)水平與腦微齣血(cerebral microbleeds,CMBs)的相關性.方法 納入急性缺血性卒中患者,應用磁敏感加權成像確定CMBs的存在,應用顆粒增彊免疫比濁法測定血清CysC水平.結果 共納入485例急性缺血性卒中患者,其中151例存在CMBs(31.1％).CMBs組血清CysC水平顯著高于非CMBs組[(1.24±0.13)mg/L對(1.02±0.11) mg/L;=4.261,P＜0.001].多變量logistic迴歸分析顯示,血清CysC水平增高是急性缺血性卒中患者存在CMBs的獨立危險因素(每增高1箇標準差優勢比4.063,95％可信區間2.142～8.127;p＜0.001);多重線性迴歸分析顯示,校正其他混雜因素後,急性缺血性卒中患者CMBs數量隨著血清CysC水平的升高而增多(r2=0.361,P=0.017).結論 在急性缺血性卒中患者中,血清CysC水平與CMBs獨立相關,且CMBs數量隨著血清CysC水平的升高而增多.
목적 탐토급성뇌경사환자혈청광억소C(cystatin C,CysC)수평여뇌미출혈(cerebral microbleeds,CMBs)적상관성.방법 납입급성결혈성졸중환자,응용자민감가권성상학정CMBs적존재,응용과립증강면역비탁법측정혈청CysC수평.결과 공납입485례급성결혈성졸중환자,기중151례존재CMBs(31.1％).CMBs조혈청CysC수평현저고우비CMBs조[(1.24±0.13)mg/L대(1.02±0.11) mg/L;=4.261,P＜0.001].다변량logistic회귀분석현시,혈청CysC수평증고시급성결혈성졸중환자존재CMBs적독립위험인소(매증고1개표준차우세비4.063,95％가신구간2.142～8.127;p＜0.001);다중선성회귀분석현시,교정기타혼잡인소후,급성결혈성졸중환자CMBs수량수착혈청CysC수평적승고이증다(r2=0.361,P=0.017).결론 재급성결혈성졸중환자중,혈청CysC수평여CMBs독립상관,차CMBs수량수착혈청CysC수평적승고이증다.
Objective To investigate the correlation between serum cystatin C (CysC) levels and cerebral microbleeds (CMBs) in patients with acute ischemic stroke.Methods The patients with acute ischemic stroke were enrolled.Susceptibility weighted imaging was used to identify the presence of CMBs.Particle-enhanced turbidimetric immunoassay was used to detect the levels of serum CysC.Results A total of 485 patients with acute ischemic stroke were enrolled,including 151 (31.1％) with CMBs.The level of serum CysC of the CMB group was significantly higher than that of the non-CMB group (1.24± 0.13 mg/L vs.1.02± 0.11 rmg/L; t=4.261,P＜ 0.001).Multivariate logistic regression analysis showed that the increased serum CysC level was an independent risk factor for the presence of CMBs in patients with acute ischemic stroke (each increase in one standard deviation,odds ratio 4.063,95％ confidence interval 2.142-8.127; P ＜0.001).Multiple linear regression analysis showed that the number of CMBs in patients with acute ischemic stroke increased with the increasing serum CysC level after adjusting for other confounders (r2 =0.361,P =0.017).Conclusions In patients with acute ischemic stroke,the serum CysC levels are independently associated with the CMBs,and the number of CMBs increases with the serum CysC level.
