CAJ | 학술논문

目的：探讨重组人脑钠肽（rhBNP）治疗充血性心力衰竭患者的临床疗效及其机制。方法：将2011年1月－2013年12月住院治疗的充血性心力衰竭患者100例随机分为研究组和对照组各50例，两组在常规治疗基础上分别应用rhBNP和硝普钠治疗，比较两组的临床效果。结果：住院期间研究组与对照组的住院时间、心功能无明显差异，但研究组非致死性心脑血管事件、病死率和不良反应发生率明显低于对照组（P＜0．05）。结论：重组人脑钠肽治疗充血性心力衰竭有效、安全。
목적：탐토중조인뇌납태（rhBNP）치료충혈성심력쇠갈환자적림상료효급기궤제。방법：장2011년1월－2013년12월주원치료적충혈성심력쇠갈환자100례수궤분위연구조화대조조각50례，량조재상규치료기출상분별응용rhBNP화초보납치료，비교량조적림상효과。결과：주원기간연구조여대조조적주원시간、심공능무명현차이，단연구조비치사성심뇌혈관사건、병사솔화불량반응발생솔명현저우대조조（P＜0．05）。결론：중조인뇌납태치료충혈성심력쇠갈유효、안전。
Objective:To explore the clinical effect and the mechanism of recombinant human brain natriuretic peptide (rhBNP) for patients with congestive heart failure. Methods:100 patients with congestive heart failure were randomly divided into research group (n=50) and control group (n=50) accepted treatment of rhBNP and sodium nitroprusside based on the conventional therapy from Jan 2011 to Dec 2013. The clinical effects were compared between the two groups. Results: Compared with the control group,the hospital stays and heart function were no significantly different in the research group, but the incidence of non-fatal cardiac and cerebral vessels ,hospital mortality and adverse accident were significantly lower (P<0.05). Conclusion: It is an effective and safe agent that patients with congestive heart failure treated by rhBNP.