湖北体育科技
湖北體育科技
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JOURNAL OF HUBEI SPORTS SCIENCE
2015年
3期
224-227
,共4页
运动%脂肪细胞因子%胰岛素抵抗%MAPK%PI3K
運動%脂肪細胞因子%胰島素牴抗%MAPK%PI3K
운동%지방세포인자%이도소저항%MAPK%PI3K
movement%adipocytokines%insulin resistance%MAPK%P13K
靶组织胰岛素敏感性降低导致的胰岛素抵抗是许多疾病的发病基础，脂肪组织作为胰岛素主要靶器官是机体最大的储能器官，它的内分泌功能是调节能量平衡的重要因子，早已证实，脂肪与胰岛素抵抗发病有密切的相关性，其通过内分泌、自分泌、旁分泌产生瘦素、肿瘤坏死因子α、脂联素、抵抗素、白介素-6等细胞因子和激素调节血糖动态平衡，脂肪细胞因子代谢异常是引起胰岛素抵抗的重要原因之一。通过持续有氧运动、间歇有氧运动、抗阻力运动等多种方式对脂肪细胞因子表达的改善可促进胰岛素相关信号转导途径MAPK、PI3K中的关键蛋白表达进而促进胰岛素信号转导，实现改善胰岛素抵抗。
靶組織胰島素敏感性降低導緻的胰島素牴抗是許多疾病的髮病基礎，脂肪組織作為胰島素主要靶器官是機體最大的儲能器官，它的內分泌功能是調節能量平衡的重要因子，早已證實，脂肪與胰島素牴抗髮病有密切的相關性，其通過內分泌、自分泌、徬分泌產生瘦素、腫瘤壞死因子α、脂聯素、牴抗素、白介素-6等細胞因子和激素調節血糖動態平衡，脂肪細胞因子代謝異常是引起胰島素牴抗的重要原因之一。通過持續有氧運動、間歇有氧運動、抗阻力運動等多種方式對脂肪細胞因子錶達的改善可促進胰島素相關信號轉導途徑MAPK、PI3K中的關鍵蛋白錶達進而促進胰島素信號轉導，實現改善胰島素牴抗。
파조직이도소민감성강저도치적이도소저항시허다질병적발병기출，지방조직작위이도소주요파기관시궤체최대적저능기관，타적내분비공능시조절능량평형적중요인자，조이증실，지방여이도소저항발병유밀절적상관성，기통과내분비、자분비、방분비산생수소、종류배사인자α、지련소、저항소、백개소-6등세포인자화격소조절혈당동태평형，지방세포인자대사이상시인기이도소저항적중요원인지일。통과지속유양운동、간헐유양운동、항조력운동등다충방식대지방세포인자표체적개선가촉진이도소상관신호전도도경MAPK、PI3K중적관건단백표체진이촉진이도소신호전도，실현개선이도소저항。
Insulin resistance which is caused by the decrease of insulin sensitivity in the target tissue is the basis of the pathogenesis of many diseases. While adipose tissue, which as the main target organ of insulin is the largest storage organ of the body, and its endocrine function is an important factor in the regulation of energy balance. It's confirmed that fat and the incidence of insulin resistance are closely correlated, which through endocrine, autocrine, and leptin are produced by paracrine, tumor necrosis factor α, adiponectin, resistin, interleukin-6 and other cytokines and hormones to regulate blood-sugar homeostasis. Abnormal metabolism of adipokine is one of the important causes of insulin resistance. Continuous aerobic exercise, intermittent aerobic exercise, resistive exercise and other ways to mobilize fat for energy, reduce the accumulation of fat content, which in the subcutaneous and abdominal pad, promote the transformation from local white fat to brown fat, and accelerate fat metabolism. The improvement of fat cytokine expression through movement can promote the expression of the key protein in the signal transduction pathway MAPK, PI3K and then promote the signal transduction in insulin and achieve improvement in insulin resistance. Exploring independently or combining different programs of sports can establish the bridge between the abnormal adipocytokines metabolism and the improvement of insulin resistance to provide a new basis for improving insulin resistance through movement.
