中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2015年
3期
192-194
,共3页
前列腺肿瘤%前列腺特异抗原%抗菌药%穿刺术
前列腺腫瘤%前列腺特異抗原%抗菌藥%穿刺術
전렬선종류%전렬선특이항원%항균약%천자술
Prostatic neoplasms%Prostate-specific antigen%Anti-bacterial agents%Punctures
目的 探讨前列腺特异性抗原(PSA)、游离前列腺特异性抗原(FPSA)水平经抗生素治疗后变化幅度对前列腺癌诊断的价值.方法 对85例PSA升高的患者进行抗生素治疗(左氧氟沙星静脉滴注1周).治疗前后均检测PSA、FPSA,患者均进行前列腺穿刺活检.分析治疗前后PSA、FPSA的变化与穿刺活检阳性的关系.结果 治疗后PSA和FPSA均较治疗前明显下降[(5.82± 1.61) μg/L比(7.71±1.32)μg/L、(0.80±0.14) μg/L比(0.98±0.17) μg/L],差异均有统计学意义(P＜0.05).85例患者中穿刺活检阳性10例.治疗后,PSA未下降(8例)、下降幅度＜10％(27例)、下降幅度10％～ 30％(24例)、下降幅度31％～ 50％(18例)、下降幅度＞50％(8例)进行分组,其中穿刺活检阳性分别为1例(1/8)、4例(14.8％,4/27)、3例(12.5％,3/24)、2例(2/18),0例.结论 对于PSA异常患者抗生素治疗后能够引起PSA的下降,PSA小幅下降并不意味前列腺癌的风险消失,而抗生素治疗后PSA下降幅度大于50％的患者患前列腺癌的风险降低,可予严密观察.对于不能耐受或不愿意接受前列腺穿刺活检的患者,抗生素治疗前后PSA的变化幅度对前列腺癌有辅助诊断意义.
目的 探討前列腺特異性抗原(PSA)、遊離前列腺特異性抗原(FPSA)水平經抗生素治療後變化幅度對前列腺癌診斷的價值.方法 對85例PSA升高的患者進行抗生素治療(左氧氟沙星靜脈滴註1週).治療前後均檢測PSA、FPSA,患者均進行前列腺穿刺活檢.分析治療前後PSA、FPSA的變化與穿刺活檢暘性的關繫.結果 治療後PSA和FPSA均較治療前明顯下降[(5.82± 1.61) μg/L比(7.71±1.32)μg/L、(0.80±0.14) μg/L比(0.98±0.17) μg/L],差異均有統計學意義(P＜0.05).85例患者中穿刺活檢暘性10例.治療後,PSA未下降(8例)、下降幅度＜10％(27例)、下降幅度10％～ 30％(24例)、下降幅度31％～ 50％(18例)、下降幅度＞50％(8例)進行分組,其中穿刺活檢暘性分彆為1例(1/8)、4例(14.8％,4/27)、3例(12.5％,3/24)、2例(2/18),0例.結論 對于PSA異常患者抗生素治療後能夠引起PSA的下降,PSA小幅下降併不意味前列腺癌的風險消失,而抗生素治療後PSA下降幅度大于50％的患者患前列腺癌的風險降低,可予嚴密觀察.對于不能耐受或不願意接受前列腺穿刺活檢的患者,抗生素治療前後PSA的變化幅度對前列腺癌有輔助診斷意義.
목적 탐토전렬선특이성항원(PSA)、유리전렬선특이성항원(FPSA)수평경항생소치료후변화폭도대전렬선암진단적개치.방법 대85례PSA승고적환자진행항생소치료(좌양불사성정맥적주1주).치료전후균검측PSA、FPSA,환자균진행전렬선천자활검.분석치료전후PSA、FPSA적변화여천자활검양성적관계.결과 치료후PSA화FPSA균교치료전명현하강[(5.82± 1.61) μg/L비(7.71±1.32)μg/L、(0.80±0.14) μg/L비(0.98±0.17) μg/L],차이균유통계학의의(P＜0.05).85례환자중천자활검양성10례.치료후,PSA미하강(8례)、하강폭도＜10％(27례)、하강폭도10％～ 30％(24례)、하강폭도31％～ 50％(18례)、하강폭도＞50％(8례)진행분조,기중천자활검양성분별위1례(1/8)、4례(14.8％,4/27)、3례(12.5％,3/24)、2례(2/18),0례.결론 대우PSA이상환자항생소치료후능구인기PSA적하강,PSA소폭하강병불의미전렬선암적풍험소실,이항생소치료후PSA하강폭도대우50％적환자환전렬선암적풍험강저,가여엄밀관찰.대우불능내수혹불원의접수전렬선천자활검적환자,항생소치료전후PSA적변화폭도대전렬선암유보조진단의의.
Objective To investigate the prostate cancer diagnosis value of prostate-specific antigen (PSA) and free prostate-specific antigen (FPSA) change quantity before and after antibiotic treatment in patients with abnormal PSA.Methods Eighty-five patients with elevated PSA were selected,and the patients were treated with antibiotic (levofloxacin intravenous drip for 1 week).The PSA and FPSA levels were detected before and after treatment.All of the patients underwent prostate needle puncture biopsy.The relation between the PSA,FPSA change quantity before and after treatment and the puncture biopsy positive rate were analyzed.Results The PSA and FPSA levels after treatment were significantly lower than those before treatment:(5.82 ± 1.61) μ g/L vs.(7.71 ± 1.32) μ g/L and (0.80 ± 0.14) μ g/L vs.(0.98 ± 0.17) μ g/L,there were statistical differences (P ＜ 0.05).In 85 patients,10 cases were puncture biopsy positive.After treatment,no PSA change was in 8 cases,PSA decreased ＜ 10％ was in 27 cases,PSA decreased 10％-30％ in 24 cases,PSA decreased 31％-50％ was in 18 cases,and PSA decreased ＞ 50％ was in 8 eases,and puncture biopsy positive were 1 case (1/8),4 cases (14.8％,4/27),3 cases (12.5％,3/24),2 cases (2/18),0case,respectively.Conclusions The PSA can decrease after antibiotic treatment in patients with abnormal PSA,and small decrease of PSA does not mean that the risk of prostate cancer disappears,but the PSA decrease ＞ 50％ after antibiotic treatment means the risk of prostate cancer decreases,which may be closely observed.In patients unable to tolerate or unwilling to accept the prostate needle puncture biopsy,the PSA change quantity before and after antibiotic treatment can help to diagnose prostate cancer.
