CAJ | 학술논문

18F-氟化钠（18F-NaF）作为骨扫描示踪剂已有50多年的历史，期间由于正电子探测器的缺乏等因素被99Tcm-MDP替代。随着PET/CT的发展，将18F-NaF作为PET/CT示踪剂的研究逐渐增多。18F-NaF本身的药物特性以及PET/CT相对于SPECT/CT的优势，使得18F-NaF PET/CT诊断恶性肿瘤骨转移的灵敏度、特异度优于99Tcm-MDP骨扫描。与99Tcm-MDP骨显像、18F-FDG PET/CT和MRI相比，18F-NaF PET/CT在诊断恶性肿瘤骨转移时具有更高的灵敏度，并且对于不同肿瘤的骨转移有不同的诊断价值。18F-NaF联合18F-FDG PET/CT扫描被证明具有一定的应用价值。18F-NaF PET/CT是诊断恶性肿瘤骨转移的安全、有效、简便、无创的方法。
18F-불화납（18F-NaF）작위골소묘시종제이유50다년적역사，기간유우정전자탐측기적결핍등인소피99Tcm-MDP체대。수착PET/CT적발전，장18F-NaF작위PET/CT시종제적연구축점증다。18F-NaF본신적약물특성이급PET/CT상대우SPECT/CT적우세，사득18F-NaF PET/CT진단악성종류골전이적령민도、특이도우우99Tcm-MDP골소묘。여99Tcm-MDP골현상、18F-FDG PET/CT화MRI상비，18F-NaF PET/CT재진단악성종류골전이시구유경고적령민도，병차대우불동종류적골전이유불동적진단개치。18F-NaF연합18F-FDG PET/CT소묘피증명구유일정적응용개치。18F-NaF PET/CT시진단악성종류골전이적안전、유효、간편、무창적방법。
18F-NaF has been used for the tracer of bone scans more than 50 years. After a period of decline for the shortage of positron detector, scholars using 18F-NaF as radioactive tracer is increasing with the development of PET/CT. The natural medicinal property of 18F-NaF and the advantage of PET make the 18F-NaF PET/CT a better way to assess malignant osseous metastases than 99Tcm-MDP bone scan in sensitivity and specificity. When compared with 99Tcm-MDP bone scan, 18F-FDG PET/CT and magnetic resonance imaging, 18F-NaF PET/CT has higher sensitivity in detecting osseous metastases of malignancies. 18F-NaF PET/CT also has different diagnostic values in management of patients with malignancies. Combine 18F-NaF and 18F-FDG in one PET/CT examination is proven to have potential in clinical management. 18F-NaF PET/CT is a safe, effective, simple and noninvasive method in diagnosis of bone metastases in malignant tumor.