国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2015年
2期
195-198,封3
,共5页
白细胞介素-27%细胞因子%人类免疫缺陷病毒%乙肝病毒
白細胞介素-27%細胞因子%人類免疫缺陷病毒%乙肝病毒
백세포개소-27%세포인자%인류면역결함병독%을간병독
Interleukin-27%Cytokine%HIV%HBV
白细胞介素-27(IL-27)是IL-6/IL-12细胞因子家族成员之一,由EBI3和p28两个亚基构成异源二聚体,主要来源于树突状细胞(DCs)的分泌.IL-27受体(IL-27R)由WSX-1与gpl30共同组成,多种细胞中均有IL-27R的表达.IL-27对免疫细胞尤其Th1细胞、Th2细胞、Th17细胞、调节性T细胞(Treg)的发育、分化和功能都发挥着不可或缺的作用,它具有免疫促进和免疫抑制双重特点.IL-27的抗病毒作用一直是近年研究的热点,它在抗HIV的研究中较多,对HBV的抗病毒作用也得到了证实.因而IL-27在抗病毒复制中发挥重要作用.
白細胞介素-27(IL-27)是IL-6/IL-12細胞因子傢族成員之一,由EBI3和p28兩箇亞基構成異源二聚體,主要來源于樹突狀細胞(DCs)的分泌.IL-27受體(IL-27R)由WSX-1與gpl30共同組成,多種細胞中均有IL-27R的錶達.IL-27對免疫細胞尤其Th1細胞、Th2細胞、Th17細胞、調節性T細胞(Treg)的髮育、分化和功能都髮揮著不可或缺的作用,它具有免疫促進和免疫抑製雙重特點.IL-27的抗病毒作用一直是近年研究的熱點,它在抗HIV的研究中較多,對HBV的抗病毒作用也得到瞭證實.因而IL-27在抗病毒複製中髮揮重要作用.
백세포개소-27(IL-27)시IL-6/IL-12세포인자가족성원지일,유EBI3화p28량개아기구성이원이취체,주요래원우수돌상세포(DCs)적분비.IL-27수체(IL-27R)유WSX-1여gpl30공동조성,다충세포중균유IL-27R적표체.IL-27대면역세포우기Th1세포、Th2세포、Th17세포、조절성T세포(Treg)적발육、분화화공능도발휘착불가혹결적작용,타구유면역촉진화면역억제쌍중특점.IL-27적항병독작용일직시근년연구적열점,타재항HIV적연구중교다,대HBV적항병독작용야득도료증실.인이IL-27재항병독복제중발휘중요작용.
Interleukin-27 (IL-27) is a member of the IL-6/IL-12 cytokine family that consists of Epstein-Barr virus induced gene 3 (EBI3) subunit and p28 subunit.It is mainly secreted by dendritic cells (DCs).IL-27 receptor,which is composed by WSX-1 and gpl30,is expressed by a variety of cells.IL-27 plays an important role on the development,differentiation and function of immunocells,especially Th1 cells,Th2 cells,Th17 cells and Treg cells.IL-27 has both promoting and inhibitory effect on the immune response.The antiviral effect of IL-27 has been a research hotspot in recent years.The anti HIV-1 and antiviral HBV effect of IL-27 has also been demonstrated.In short,IL-27 plays an important role in the antiviral responses.
