中华地方病学杂志
中華地方病學雜誌
중화지방병학잡지
Chinese Journal of Endemiology
2015年
3期
225-230
,共6页
张亚平%黄嫣红%伍啸青%邵慧琳%洪清祺%李呐%张淑琼
張亞平%黃嫣紅%伍嘯青%邵慧琳%洪清祺%李吶%張淑瓊
장아평%황언홍%오소청%소혜림%홍청기%리눌%장숙경
碘%尿%比重%浓度校正
碘%尿%比重%濃度校正
전%뇨%비중%농도교정
Iodine%Urine%Specific gravity%Concentration correction
目的 探讨采用尿比重校正尿碘浓度的合理性.方法 分别采用电子天平称重法(简称称重法)和数字式尿液比重折射计法(简称折射计法)测量质量浓度为10～30 g/L的不同无机盐(氯化钠、硫酸钠、磷酸二氢铵)、有机物(尿素、葡萄糖、甘氨酸)水溶液比重,以及尿样外加10～ 30 g/L氯化钠或尿素时尿液比重.采用砷铈催化分光光度法(WS/T 107-2006)、称重法和折射计法测定27份孕妇尿样的尿碘浓度和比重,分别用直接表示、称重法比重校正、折射计法比重校正表示尿碘结果并进行比较.在不同季节分别6批次采集8～10岁学生和孕妇的1次即时尿样,测定折射计法尿比重和尿碘浓度,比较尿碘浓度校正与否的结果.结果 ①称重法测得比重为无机盐(氯化钠、硫酸钠、磷酸二氢铵)水溶液大于相同质量浓度的有机物(尿素、葡萄糖、甘氨酸)水溶液,10 g/L氯化钠溶液的比重(1.008)比30 g/L尿素溶液的比重(1.006)大.②称重法测得3份尿样加10 g/L氯化钠时对应比重分别增加0.006、0.008、0.007,而加10 g/L尿素时对应比重分别增加0.003、0.002、0.004.③27份孕妇尿样尿碘浓度直接表示、称重法比重校正、折射计法比重校正的结果中位数分别为106.4、165.2、211.8 μg/L.④6批次8～10岁学生尿样的折射计法尿比重中位数在1.019 0～1.021 2 g/cm3,尿碘结果直接表示及折射计法比重校正表示的中位数分别在134.5 ～ 181.7、157.7～190.4 μg/L;6批次孕妇尿样的折射计法尿比重中位数在1.013 4～1.017 1 g/cm3,尿碘结果直接表示及折射计法比重校正表示的中位数分别在96.2～138.9、135.2～181.6 μg/L.结论 尿中氯化钠浓度变化是尿比重变化的最主要原因.基于我国人群尿中碘的主要来源是人食用加碘食盐,加碘食盐摄入量直接影响尿比重和尿碘浓度,若以尿比重来校正尿碘浓度,会出现摄入加碘食盐量越低致尿比重越低,尿碘浓度经校正“被增高”越多;反之摄入加碘食盐量越高致尿比重越高,尿碘浓度经校正“被减低”越多的不合理现象,因此不能以尿比重来校正尿碘浓度.
目的 探討採用尿比重校正尿碘濃度的閤理性.方法 分彆採用電子天平稱重法(簡稱稱重法)和數字式尿液比重摺射計法(簡稱摺射計法)測量質量濃度為10～30 g/L的不同無機鹽(氯化鈉、硫痠鈉、燐痠二氫銨)、有機物(尿素、葡萄糖、甘氨痠)水溶液比重,以及尿樣外加10～ 30 g/L氯化鈉或尿素時尿液比重.採用砷鈰催化分光光度法(WS/T 107-2006)、稱重法和摺射計法測定27份孕婦尿樣的尿碘濃度和比重,分彆用直接錶示、稱重法比重校正、摺射計法比重校正錶示尿碘結果併進行比較.在不同季節分彆6批次採集8～10歲學生和孕婦的1次即時尿樣,測定摺射計法尿比重和尿碘濃度,比較尿碘濃度校正與否的結果.結果 ①稱重法測得比重為無機鹽(氯化鈉、硫痠鈉、燐痠二氫銨)水溶液大于相同質量濃度的有機物(尿素、葡萄糖、甘氨痠)水溶液,10 g/L氯化鈉溶液的比重(1.008)比30 g/L尿素溶液的比重(1.006)大.②稱重法測得3份尿樣加10 g/L氯化鈉時對應比重分彆增加0.006、0.008、0.007,而加10 g/L尿素時對應比重分彆增加0.003、0.002、0.004.③27份孕婦尿樣尿碘濃度直接錶示、稱重法比重校正、摺射計法比重校正的結果中位數分彆為106.4、165.2、211.8 μg/L.④6批次8～10歲學生尿樣的摺射計法尿比重中位數在1.019 0～1.021 2 g/cm3,尿碘結果直接錶示及摺射計法比重校正錶示的中位數分彆在134.5 ～ 181.7、157.7～190.4 μg/L;6批次孕婦尿樣的摺射計法尿比重中位數在1.013 4～1.017 1 g/cm3,尿碘結果直接錶示及摺射計法比重校正錶示的中位數分彆在96.2～138.9、135.2～181.6 μg/L.結論 尿中氯化鈉濃度變化是尿比重變化的最主要原因.基于我國人群尿中碘的主要來源是人食用加碘食鹽,加碘食鹽攝入量直接影響尿比重和尿碘濃度,若以尿比重來校正尿碘濃度,會齣現攝入加碘食鹽量越低緻尿比重越低,尿碘濃度經校正“被增高”越多;反之攝入加碘食鹽量越高緻尿比重越高,尿碘濃度經校正“被減低”越多的不閤理現象,因此不能以尿比重來校正尿碘濃度.
목적 탐토채용뇨비중교정뇨전농도적합이성.방법 분별채용전자천평칭중법(간칭칭중법)화수자식뇨액비중절사계법(간칭절사계법)측량질량농도위10～30 g/L적불동무궤염(록화납、류산납、린산이경안)、유궤물(뇨소、포도당、감안산)수용액비중,이급뇨양외가10～ 30 g/L록화납혹뇨소시뇨액비중.채용신시최화분광광도법(WS/T 107-2006)、칭중법화절사계법측정27빈잉부뇨양적뇨전농도화비중,분별용직접표시、칭중법비중교정、절사계법비중교정표시뇨전결과병진행비교.재불동계절분별6비차채집8～10세학생화잉부적1차즉시뇨양,측정절사계법뇨비중화뇨전농도,비교뇨전농도교정여부적결과.결과 ①칭중법측득비중위무궤염(록화납、류산납、린산이경안)수용액대우상동질량농도적유궤물(뇨소、포도당、감안산)수용액,10 g/L록화납용액적비중(1.008)비30 g/L뇨소용액적비중(1.006)대.②칭중법측득3빈뇨양가10 g/L록화납시대응비중분별증가0.006、0.008、0.007,이가10 g/L뇨소시대응비중분별증가0.003、0.002、0.004.③27빈잉부뇨양뇨전농도직접표시、칭중법비중교정、절사계법비중교정적결과중위수분별위106.4、165.2、211.8 μg/L.④6비차8～10세학생뇨양적절사계법뇨비중중위수재1.019 0～1.021 2 g/cm3,뇨전결과직접표시급절사계법비중교정표시적중위수분별재134.5 ～ 181.7、157.7～190.4 μg/L;6비차잉부뇨양적절사계법뇨비중중위수재1.013 4～1.017 1 g/cm3,뇨전결과직접표시급절사계법비중교정표시적중위수분별재96.2～138.9、135.2～181.6 μg/L.결론 뇨중록화납농도변화시뇨비중변화적최주요원인.기우아국인군뇨중전적주요래원시인식용가전식염,가전식염섭입량직접영향뇨비중화뇨전농도,약이뇨비중래교정뇨전농도,회출현섭입가전식염량월저치뇨비중월저,뇨전농도경교정“피증고”월다;반지섭입가전식염량월고치뇨비중월고,뇨전농도경교정“피감저”월다적불합리현상,인차불능이뇨비중래교정뇨전농도.
Objective To explore the rationality of correcting urinary iodine (UI) concentration by using urine specific gravity (U-SG).Methods Weighing method and refractometer method were used respectively to measure specific gravity of 10-30 g/L mass concentration of different inorganic salts (sodium chloride,sodium sulfate,ammonium biphosphate) and organic matters(urea,glucose,glycine) aqueous solution,and urine plus 10-30 g/L sodium chloride or urea.UI concentrations in urine samples of 27 pregnant women respectively were expressed by direct method,weighing method U-SG correction and refractometer method U-SG correction.One random urine sample was collected for six batches in different seasons from children aged 8-10 and pregnant women for determination of U-SG and UI concentration.UI concentration was determined by arsenic cerium catalytic spectrophotometry (WS/T 107-2006).Results ①Measured by weighing method,specific gravity of inorganic salt (sodium chloride,sodium sulfate,ammonium biphosphate) aqueous solution was significantly greater than that of organic matters (urea,glucose,glycine) aqueous solution which had the same mass concentration.The specific gravity of 10 g/L sodium chloride aqueous solution was 1.008,and that of 30 g/L urea solution was 1.006.②Measured by weighing method,10 g/L sodium chloride was added to 3 urine samples separately.Accordingly the increases of USG were 0.006,0.008 and 0.007,respectively.Otherwise,the increases of U-SG were 0.003,0.002 and 0.004,respectively,when adding 10 g/L urea.~he median results of UI concentrations in urine samples from 27 pregnant women were 106.4,165.2 and 211.8 μg/L,respectively,expressing obtained by direct method,weighing method USG correction and refractometer method U-SG correction.④The determination results of six batches urine collected from children aged 8-10 in different seasons,the median results of U-SG measured by refractometer method were 1.019 0-1.021 2,the median UI concentration results obtained by direct method and refractometer method U-SG correction were 134.5-181.7 μg/L and 157.7-190.4 μg/L.The determination results of six batches urine samples of pregnant women in different seasons,the median results of U-SG measured by refractometer method were 1.013 4 -1.017 1,the median UI concentration results obtained by direct method and refractometer method U-SG correction were 96.2-138.9 μg/L and 135.2-181.6 μg/L.Conclusions The change of sodium chloride concentration in urine is the most important reason for the change of U-SG.In China,the main source of UI is the intake of edible iodized salt.Iodized salt intakes directly affect the U-SG and UI concentration.If the U-SG is used to correct the UI concentration,there will be a phenomena that the lower intake of iodized salt the lower U-SG.So the UI concentration was falsely increased significantly after correction.Conversely higher intakes of iodized salt caused higher U-SG.The UI concentration was falsely reduced significantly after correction.Therefore,U-SG cannot be used to correct the UI concentration.
