CAJ | 학술논문

目的了解宝鸡市碘缺乏病防治效果,为碘缺乏病决策和调整干预措施提供必要的信息.方法收集2008年11月至2013年10月在宝鸡市妇幼保健院筛查的先天性新生儿甲状腺功能减低症(CH)的基本资料,包括促甲状腺激素(TSH)、总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸wT3)、总甲状腺素(TT4)、游离甲状腺素(FT4)等,并进行描述性分析.另外,于2013年,在宝鸡市所辖的12个县区,每个县区按东、西、南、北、中划分为5个片区,在每个片区各抽取12名孕妇,收集其一次性尿样5ml;在宝鸡市的东、西、南、北、中5个方位,各抽取3名已确诊为新生儿CH患儿的生母(在其生产1年后),收集其一次性尿样5ml,采用砷铈催化分光光度测定法(WS/T 107-2006)检测尿碘.结果 2008-2013年,宝鸡市共筛查新生儿198 575例,其中确诊新生儿CH 68例,检出率为0.34‰;TSH＞ 5.0 mU/L的有9 937人,检出率为5.00％;TSH≥8.5 mU/L的有94例.共检测720名孕妇尿样,尿碘中位数为218.57μg/L,尿碘＜150.00 μg/L的有222人,占30.83％(222/720);共检测15名CH患儿生母尿样,尿碘中位数为362.80 μg/L.结论宝鸡市孕妇碘营养状况良好,新生儿CH发病的检出率低于全国平均水平(0.49‰).今后的工作中应加强妊娠妇女的尿碘监测,尽可能消除碘缺乏对新生儿的影响.
목적 료해보계시전결핍병방치효과,위전결핍병결책화조정간예조시제공필요적신식.방법 수집2008년11월지2013년10월재보계시부유보건원사사적선천성신생인갑상선공능감저증(CH)적기본자료,포괄촉갑상선격소(TSH)、총삼전갑상선원안산(TT3)、유리삼전갑상선원안산wT3)、총갑상선소(TT4)、유리갑상선소(FT4)등,병진행묘술성분석.령외,우2013년,재보계시소할적12개현구,매개현구안동、서、남、북、중화분위5개편구,재매개편구각추취12명잉부,수집기일차성뇨양5ml;재보계시적동、서、남、북、중5개방위,각추취3명이학진위신생인CH환인적생모(재기생산1년후),수집기일차성뇨양5ml,채용신시최화분광광도측정법(WS/T 107-2006)검측뇨전.결과 2008-2013년,보계시공사사신생인198 575례,기중학진신생인CH 68례,검출솔위0.34‰;TSH＞ 5.0 mU/L적유9 937인,검출솔위5.00％;TSH≥8.5 mU/L적유94례.공검측720명잉부뇨양,뇨전중위수위218.57μg/L,뇨전＜150.00 μg/L적유222인,점30.83％(222/720);공검측15명CH환인생모뇨양,뇨전중위수위362.80 μg/L.결론 보계시잉부전영양상황량호,신생인CH발병적검출솔저우전국평균수평(0.49‰).금후적공작중응가강임신부녀적뇨전감측,진가능소제전결핍대신생인적영향.
Objective To understand the control effect of iodine deficiency disorders (IDD) in Baoji City,and to provide necessary information for decision-making and adjustment of IDD intervention.Methods From November 2008 to October 2013,basic information of congenital hypothyroidism (CH) was collected in Child Health Hospital of Baoji City,including thyroid stimulating hormone (TSH),three total triiodothyronine (TT3),free triiodothyronine (FT3),total thyroxine (TT4),free thyroxine (FT4),and descriptive analysis was conducted.In 2013,12 counties of Baoji City were selected; each county was divided into east,west,south,north and center parts; 12 pregnant women were selected in each part,and a disposable urine sample (5 ml) was collected; in the east,west,south,north and center parts of Baoji City,3 mothers whose children had been diagnosed neonatal CH (1 years after giving birth) were selected,and a disposable urine sample (5 ml) was collected.Urinary iodine was detected by arsenic cerium catalytic spectrophotometry (WS/T 107-2006).Results In 2008-2013,a total of 198 575 cases of neonatal were screened,of which 68 cases were diagnosed as neonatal CH,the detection rate was 0.34 per thousand; TSH ＞ 5.0 mU/L was 9 937,the detection rate was 5.00％; TSH ≥ 8.5 mU/L was 94.A total of 720 pregnant women were examined,the median of urinary iodine was 218.57 μg/L,＜ 150.00 μg/L was 222 people,accounted for 30.83％ (222/720).A total of postpartum mothers were examined,the median of urinary iodine was 362.80 μg/L,there was no significant difference between pregnant women with postpartum mothers (P ＞ 0.05).Conclusions In Baoji City,iodine nutritional status of pregnant women is good,and the detection rate of CH is lower than the national average level (0.49‰).The monitoring of urinary iodine of pregnant women should be strengthened in the future to eliminate the influence of iodine deficiency on neonates.