中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2015年
2期
142-144
,共3页
肝硬化%血糖%高脂血症%糖尿病%肝硬化/并发症
肝硬化%血糖%高脂血癥%糖尿病%肝硬化/併髮癥
간경화%혈당%고지혈증%당뇨병%간경화/병발증
Liver cirrhosis%Blood glucose%Hyperlipidemia%Diabetes mellitus%Live cirhosis/complications
目的 观察血糖和血脂水平变化以及糖尿病对肝硬化患者疾病恶化的影响.方法 对2010-2014年,宁波慈溪市人民医院收治268例肝硬化患者,根据Child-Pugh评分标准分为三组,比较三组患者血糖、血脂水平以及糖尿病的发生率,并进一步观察糖尿病对肝硬化患者肝肾功能以及并发症的影响.结果 Child B级和C级肝硬化患者糖尿病的发生率明显高于Child A级,P=0.004,而三组空腹血糖受损(IFG)的发生率无统计学差异,P=0.819;Child B级和C级肝硬化患者总胆固醇(TC)水平明显要低于Child A级,P＜0.01;而三组空腹血糖、甘油三脂(TG)水平差异无统计学意义,P =0.558,0.169.合并糖尿病的肝硬化患者血清白蛋白(ALB)水平明显低于无糖尿病的患者,P=0.009;合并糖尿病的肝硬化患者腹水、消化道出血、肝性脑病并发症发生率均明显高于无糖尿病的患者,P ＜0.01.结论 肝硬化患者糖代谢异常发生率更高,且合并的糖尿病会促进肝硬化的恶化.
目的 觀察血糖和血脂水平變化以及糖尿病對肝硬化患者疾病噁化的影響.方法 對2010-2014年,寧波慈溪市人民醫院收治268例肝硬化患者,根據Child-Pugh評分標準分為三組,比較三組患者血糖、血脂水平以及糖尿病的髮生率,併進一步觀察糖尿病對肝硬化患者肝腎功能以及併髮癥的影響.結果 Child B級和C級肝硬化患者糖尿病的髮生率明顯高于Child A級,P=0.004,而三組空腹血糖受損(IFG)的髮生率無統計學差異,P=0.819;Child B級和C級肝硬化患者總膽固醇(TC)水平明顯要低于Child A級,P＜0.01;而三組空腹血糖、甘油三脂(TG)水平差異無統計學意義,P =0.558,0.169.閤併糖尿病的肝硬化患者血清白蛋白(ALB)水平明顯低于無糖尿病的患者,P=0.009;閤併糖尿病的肝硬化患者腹水、消化道齣血、肝性腦病併髮癥髮生率均明顯高于無糖尿病的患者,P ＜0.01.結論 肝硬化患者糖代謝異常髮生率更高,且閤併的糖尿病會促進肝硬化的噁化.
목적 관찰혈당화혈지수평변화이급당뇨병대간경화환자질병악화적영향.방법 대2010-2014년,저파자계시인민의원수치268례간경화환자,근거Child-Pugh평분표준분위삼조,비교삼조환자혈당、혈지수평이급당뇨병적발생솔,병진일보관찰당뇨병대간경화환자간신공능이급병발증적영향.결과 Child B급화C급간경화환자당뇨병적발생솔명현고우Child A급,P=0.004,이삼조공복혈당수손(IFG)적발생솔무통계학차이,P=0.819;Child B급화C급간경화환자총담고순(TC)수평명현요저우Child A급,P＜0.01;이삼조공복혈당、감유삼지(TG)수평차이무통계학의의,P =0.558,0.169.합병당뇨병적간경화환자혈청백단백(ALB)수평명현저우무당뇨병적환자,P=0.009;합병당뇨병적간경화환자복수、소화도출혈、간성뇌병병발증발생솔균명현고우무당뇨병적환자,P ＜0.01.결론 간경화환자당대사이상발생솔경고,차합병적당뇨병회촉진간경화적악화.
Objective To explore the impact of glucose and lipid metabolism and diabetes on the progression of disease in patients with cirrhosis.Methods A total of 268 cases of patients with cirrhosis,treated at our hospital from 2010 to 2014,were divided into three groups according to standard of Child-Pugh grading score.The blood glucose,blood lipid leveland the incidence of diabetes mellitus (DM) were observed and compared respectively.The impact of diabetes on liver and renal function and complication in patients with cirrhosis was further observed.Results The incidence of DM in patients with cirrhosis of Child-Pugh B and C was singnifcantly higher than that of Child-Pugh A,P =0.004,while there was no significant difference in impaired fasting blood glucose(IFG),P =0.819.The level of total cholesterol (TC) in patients with cirrhosis of Child-Pugh B and C was obviously lower than that of Child-Pugh A,P =0.000,while the levels of fasting blood glucose,triglycerides (TG) in patients with different Child-Pugh score had no statistically significant difference,P =0.558,0.169.The level of serum albumin (ALB) of patients with DM in cirrhosis was significantly lower than those without DM,P =0.009.The patients with DM in liver cirrhosis had higher incidence of complications such as ascites,gastro esophageal variceal bleeding(GEVB) or hepatic encephalopathy than those without DM,P =0.000.Conclusion The patients with cirrhosis had higher incidence of abnormal glucose metabolism,and DM lead to progression of liver disease in turn.
