中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2015年
2期
145-147
,共3页
臧红%严福明%游绍莉%朱冰%刘婉姝%万志红%刘鸿凌%李晨%貌盼勇
臧紅%嚴福明%遊紹莉%硃冰%劉婉姝%萬誌紅%劉鴻凌%李晨%貌盼勇
장홍%엄복명%유소리%주빙%류완주%만지홍%류홍릉%리신%모반용
巨细胞病毒%肝功能衰竭%临床特征%预后
巨細胞病毒%肝功能衰竭%臨床特徵%預後
거세포병독%간공능쇠갈%림상특정%예후
Cytomegalovirus%Liver failure%Clinical features%Prognosis
目的 探讨巨细胞病毒性肝衰竭患者的临床特征及预后.方法 回顾性分析总结38例巨细胞病毒性肝衰竭患者的临床资料.结果 患者年龄在2个月～ 75岁,成人12例(31.58％),除外各种诱因后仍有6例发病前为健康成人(15.79％).临床分型以急性、亚急性为主(76.32％),症状以纳差(60.53％)、发热多见(57.89％),生化指标恶化组患者白蛋白、胆碱酯酶低于改善组,总胆红素高于改善组(P＜0.05),而凝血酶原活动度间无明显差异.并发症以肝性脑病、腹水、上呼吸道感染为主.经治疗总体改善率31.58％,其中成人患者的改善率仅为16.67％.患者的年龄、肝性脑病是影响预后的独立危险因素.结论 巨细胞病毒性肝衰竭以急性、亚急性为主,年龄不同临床表现不尽相同.健康成人感染巨细胞病毒后可进展为肝衰竭,预后差.患者的年龄、肝性脑病是影响预后的独立危险因素.
目的 探討巨細胞病毒性肝衰竭患者的臨床特徵及預後.方法 迴顧性分析總結38例巨細胞病毒性肝衰竭患者的臨床資料.結果 患者年齡在2箇月～ 75歲,成人12例(31.58％),除外各種誘因後仍有6例髮病前為健康成人(15.79％).臨床分型以急性、亞急性為主(76.32％),癥狀以納差(60.53％)、髮熱多見(57.89％),生化指標噁化組患者白蛋白、膽堿酯酶低于改善組,總膽紅素高于改善組(P＜0.05),而凝血酶原活動度間無明顯差異.併髮癥以肝性腦病、腹水、上呼吸道感染為主.經治療總體改善率31.58％,其中成人患者的改善率僅為16.67％.患者的年齡、肝性腦病是影響預後的獨立危險因素.結論 巨細胞病毒性肝衰竭以急性、亞急性為主,年齡不同臨床錶現不儘相同.健康成人感染巨細胞病毒後可進展為肝衰竭,預後差.患者的年齡、肝性腦病是影響預後的獨立危險因素.
목적 탐토거세포병독성간쇠갈환자적림상특정급예후.방법 회고성분석총결38례거세포병독성간쇠갈환자적림상자료.결과 환자년령재2개월～ 75세,성인12례(31.58％),제외각충유인후잉유6례발병전위건강성인(15.79％).림상분형이급성、아급성위주(76.32％),증상이납차(60.53％)、발열다견(57.89％),생화지표악화조환자백단백、담감지매저우개선조,총담홍소고우개선조(P＜0.05),이응혈매원활동도간무명현차이.병발증이간성뇌병、복수、상호흡도감염위주.경치료총체개선솔31.58％,기중성인환자적개선솔부위16.67％.환자적년령、간성뇌병시영향예후적독립위험인소.결론 거세포병독성간쇠갈이급성、아급성위주,년령불동림상표현불진상동.건강성인감염거세포병독후가진전위간쇠갈,예후차.환자적년령、간성뇌병시영향예후적독립위험인소.
Objective To investigate clinical features and prognosis of patients with cytomegalovirus (CMV)-associated liver failure.Methods The clinical data on 38 patients with CMV-associated liver failure from two hospitals were retrospectively analyzed.Results The range of patients' ages were from 2 months to 75 years,12 adults(31.58％),including 6 patients (15.79％) were healthy previously.The predominant types of liver failure were acute and subacute liver failure (76.32％).The most frequent symptoms were anorexia (60.53％),fever (57.89％).The test results of albumin (ALB) and cholinesterase (CHE) in the deteriorated group were lower than those in the improved group,total bilirubin (TBIL) in the deteriorated group was increased more than that in the improved group,but prothrombin activity (PA) had no significant differences.The most common complications were hepatic encephalopathy,ascites,and upper respiratory tract/lung infection.The overall improved rate was 31.58％,but,the improved rate was only 16.67％ in adults.Age and hepatic encephalopathy were the independent risk factor of prognosis.Conclusions The predominant types of patients with cytomegalovirus-associated liver failure were acute and sub-acute liver failure,the clinical features varies in different age.The healthy adults infected with CMV could progress to liver failure,and the prognosis was poor.Age and hepatic encephalopathy were the independent risk factors of prognosis.
