中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2015年
4期
301-305
,共5页
孙元元%郭志%杨雪玲%王海涛
孫元元%郭誌%楊雪玲%王海濤
손원원%곽지%양설령%왕해도
前列腺肿瘤%磁共振成像%Meta分析
前列腺腫瘤%磁共振成像%Meta分析
전렬선종류%자공진성상%Meta분석
Prostatic neoplasms%Magnetic resonance imaging%Meta analysis
目的 采用Meta分析法比较PET-CT与DWI对前列腺癌淋巴结分期的诊断价值.方法 检索PubMed、EMBASE、Cochrane Library、SCI数据库有关的英文文献,并提取纳入研究的一般特征及诊断信息.统计分析采用Meta Disc 1.4软件检验异质性,根据异质性结果选择相应的效应模型,计算汇总敏感度和特异度及其95％可信区间,绘制汇总受试者工作特征(SROC)曲线,通过x2检验比较两种检查方法的敏感度及特异度、Z检验比较曲线下面积评判其诊断效能.结果 按照纳入和排除标准共获取文献11篇,其中同一研究群体同时行两种检查的3篇,PET-CT组中以11C-胆碱为显像剂的有8篇,18F-氟代胆碱为显像剂的有3篇.PET-CT组诊断前列腺癌淋巴结转移的敏感度、特异度(95％可信区间)及SROC曲线下面积分别为0.64(0.57～ 0.71)、0.93(0.90～ 0.96)、0.8795,DWI分别为0.59(0.47～ 0.70)、0.82(0.70～0.91)、0.7707.PET-CT特异度较DWI高,差异有统计学意义(x2=5.531,P＜0.05).PET-CT与DWI的敏感度差异无统计学意义(x2=0.528,P＞0.05).两种检查方法的AUC差异无统计学意义(Z=1.699,P＞0.05).结论 对于前列腺癌患者的淋巴结分期,PET-CT较DWI诊断的敏感度相当,特异度更高,诊断效能更好.
目的 採用Meta分析法比較PET-CT與DWI對前列腺癌淋巴結分期的診斷價值.方法 檢索PubMed、EMBASE、Cochrane Library、SCI數據庫有關的英文文獻,併提取納入研究的一般特徵及診斷信息.統計分析採用Meta Disc 1.4軟件檢驗異質性,根據異質性結果選擇相應的效應模型,計算彙總敏感度和特異度及其95％可信區間,繪製彙總受試者工作特徵(SROC)麯線,通過x2檢驗比較兩種檢查方法的敏感度及特異度、Z檢驗比較麯線下麵積評判其診斷效能.結果 按照納入和排除標準共穫取文獻11篇,其中同一研究群體同時行兩種檢查的3篇,PET-CT組中以11C-膽堿為顯像劑的有8篇,18F-氟代膽堿為顯像劑的有3篇.PET-CT組診斷前列腺癌淋巴結轉移的敏感度、特異度(95％可信區間)及SROC麯線下麵積分彆為0.64(0.57～ 0.71)、0.93(0.90～ 0.96)、0.8795,DWI分彆為0.59(0.47～ 0.70)、0.82(0.70～0.91)、0.7707.PET-CT特異度較DWI高,差異有統計學意義(x2=5.531,P＜0.05).PET-CT與DWI的敏感度差異無統計學意義(x2=0.528,P＞0.05).兩種檢查方法的AUC差異無統計學意義(Z=1.699,P＞0.05).結論 對于前列腺癌患者的淋巴結分期,PET-CT較DWI診斷的敏感度相噹,特異度更高,診斷效能更好.
목적 채용Meta분석법비교PET-CT여DWI대전렬선암림파결분기적진단개치.방법 검색PubMed、EMBASE、Cochrane Library、SCI수거고유관적영문문헌,병제취납입연구적일반특정급진단신식.통계분석채용Meta Disc 1.4연건검험이질성,근거이질성결과선택상응적효응모형,계산회총민감도화특이도급기95％가신구간,회제회총수시자공작특정(SROC)곡선,통과x2검험비교량충검사방법적민감도급특이도、Z검험비교곡선하면적평판기진단효능.결과 안조납입화배제표준공획취문헌11편,기중동일연구군체동시행량충검사적3편,PET-CT조중이11C-담감위현상제적유8편,18F-불대담감위현상제적유3편.PET-CT조진단전렬선암림파결전이적민감도、특이도(95％가신구간)급SROC곡선하면적분별위0.64(0.57～ 0.71)、0.93(0.90～ 0.96)、0.8795,DWI분별위0.59(0.47～ 0.70)、0.82(0.70～0.91)、0.7707.PET-CT특이도교DWI고,차이유통계학의의(x2=5.531,P＜0.05).PET-CT여DWI적민감도차이무통계학의의(x2=0.528,P＞0.05).량충검사방법적AUC차이무통계학의의(Z=1.699,P＞0.05).결론 대우전렬선암환자적림파결분기,PET-CT교DWI진단적민감도상당,특이도경고,진단효능경호.
Objective To assess and compare the overall diagnostic value of positron emission tomography(PET)-CT and DWI in lymph node staging in patients with prostate cancer by using Meta-analysis.Methods Relevant English articles published on PubMed,EMBASE,Cochrane Library and SCI database were searched.Subsequently,the characteristics of the included articles were appraised and extracted.Statistical analysis was performed employing Meta Disc version 1.4.Heterogeneity of the included articles was tested,which was used to select proper effect model to calculate the pooled sensitivity and specificity and the corresponding 95％ CI,summary receiver operating characteristics(SROC) curve was performed and the area under the curve was calculated.The diagnostic performanceincluding the sensitivity,specificity,and the area under the curve was compared between the two groups via x2 test and Z test respectively.Results Eleven of 182 retrieved articles were included,in which 3 articles used two methods of imaging examination at the same time.In PET-CT group,there were eight articles using 11C-Choline as imaging agents,three with 18F-Fluorocholine.The pooled sensitivity and specificity and area under SROC curve for PET-CT were 0.64 (0.574.71),0.93 (0.90-0.96),and 0.8795 respectively.They were 0.59 (0.47-0.70),0.82 (0.70-0.91),and 0.7707 for DWI group.The specificity of PET-CT was significantly higher than that of DWI (x2=5.531,P＜0.05).No significant differences were found in the sensitivity and AUC between the two groups (x2=0.528,Z=1.699,P＞0.05).Conclusion For lymph node staging in patients with prostate cancer,PET-CT has an equal sensitivity and a higher specificity,a better diagnostic performance compared with DWI.
