CAJ | 학술논문

目的评价皮质-皮质间诱发电位(CCEP)在体追踪癫痫相关网络的应用价值.方法接受长程颅内电极埋置术的药物难治性癫痫患者2例.根据患者发作起始区及(电刺激功能定位所确定的)功能区分布,给予目标电极对交替极性(频率1 Hz)的电刺激.记录到的诱发电位为锁定了刺激时刻的皮质脑电图.随后,将诱发电位分布区与功能区、发作起始区进行比较.结果 2例患者均得到了较为典型的诱发电位波形,1例数据可用于在体追踪不同脑区之间的功能连接,1例数据可用于在体追踪癫痫的兴奋性网络.结论应用CCEP,可通过在体追踪癫痫患者不同脑区之间的功能连接及癫痫的兴奋性网络,来实现对癫痫相关网络的探索.
목적 평개피질-피질간유발전위(CCEP)재체추종전간상관망락적응용개치.방법 접수장정로내전겁매치술적약물난치성전간환자2례.근거환자발작기시구급(전자격공능정위소학정적)공능구분포,급여목표전겁대교체겁성(빈솔1 Hz)적전자격.기록도적유발전위위쇄정료자격시각적피질뇌전도.수후,장유발전위분포구여공능구、발작기시구진행비교.결과 2례환자균득도료교위전형적유발전위파형,1례수거가용우재체추종불동뇌구지간적공능련접,1례수거가용우재체추종전간적흥강성망락.결론 응용CCEP,가통과재체추종전간환자불동뇌구지간적공능련접급전간적흥강성망락,래실현대전간상관망락적탐색.
Objective To evaluate the cortico-cortical evoked potential (CCEP) in exploring the network in epileptics.Methods Two patients with intractable epilepsy underwent chronic intracranial electrode placement.According to the distribution of icta onset zones and the functional brain mapping,alternating 1 Hz electrical stimuli were delivered to the target electrodes.And CCEPs were recorded by averaging electrocorticograms time-locked to stimuli from subdural electrodes.Then icta onset zones,eloquent areas identified by electrical cortical mapping and CCEP distributions were compared.Results Typical CCEP responses were observed.The data of one patient was useful for investigating the connectivity associated with various brain networks while another patient was useful for evaluating the cortical excitability.Conclusion The exploration of epileptic network is achieved through cortico-cortical evoked potential by investigating the connectivity associated with various brain networks and cortical excitability.