CAJ | 학술논문

目的观察纳美芬在治疗急性一氧化碳中毒迟发性脑病所起的作用.方法对照组和实验组各100例均从200例患者中随机柚取.对照组采用一般常规治疗包括高压氧治疗,而实验组在对照组的基础上使用纳美芬治疗.观察两组的治疗效果,并通过应用蒙特利尔认知评估表(MoCA)和简易精神状态评估量表(MMSE)来评估所有患者用药前后的认知功能.结果实验组的总有效率(94％)明显高于对照组(72％),两组比较差异有统计学意义(x2=9.524,P=0.002);在MoCA和MMSE评分方面,其两组在经过治疗后分值均显著优于治疗前(P＜0.05),且与对照组相比较,实验组分值较高(P＜0.05).结论新型药物纳美芬在一氧化碳中毒迟发性脑病的治疗上效果显著,在改善患者的认知功能障碍方面效果明显.
목적 관찰납미분재치료급성일양화탄중독지발성뇌병소기적작용.방법 대조조화실험조각100례균종200례환자중수궤유취.대조조채용일반상규치료포괄고압양치료,이실험조재대조조적기출상사용납미분치료.관찰량조적치료효과,병통과응용몽특리이인지평고표(MoCA)화간역정신상태평고량표(MMSE)래평고소유환자용약전후적인지공능.결과 실험조적총유효솔(94％)명현고우대조조(72％),량조비교차이유통계학의의(x2=9.524,P=0.002);재MoCA화MMSE평분방면,기량조재경과치료후분치균현저우우치료전(P＜0.05),차여대조조상비교,실험조분치교고(P＜0.05).결론 신형약물납미분재일양화탄중독지발성뇌병적치료상효과현저,재개선환자적인지공능장애방면효과명현.
Objective To observe the curative effects of nalmefene on delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods Two hundred patients were randomly divded into control group (n =100)and experimental group (n =100)by stratified randomization method.Both of the groups were given routine therapy including hyperbaric oxygen treatment,and experimental group was treated with nalmefene in addition.The clinical curative effect of the two groups were compared after clinical treatment,the patients' scores before treatment and after treatment were assessed by mini mental state examination(MMSE) and montreal cognitive assessment scale(MoCA).Results The total effective rate of experimental group(94％)was higher than that of control group(72％).For MoCA and MMSE,the scores after treatment were higher than that before treatment in the two groups (P ＜ 0.05),and the scores of experimental group was higher than that of the control group (P ＜ 0.05).Conclusions Nalmefene in the treatment of delayed encephalopathy after acute caebon monoxide poisoning(DEACMP) may have good effect and could obviously improve the cognitive dysfunction of the patients.