中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
9期
58-59
,共2页
右美托咪啶%血流动力学%稳定性%临床分析
右美託咪啶%血流動力學%穩定性%臨床分析
우미탁미정%혈류동역학%은정성%림상분석
Dexmedetomidine%Hemodynamic%Stability%Analysis
目的 分析不同剂量右美托咪啶对诱导插管期老年高血压患者血流动力学的影响.方法 选择在北京健宫医院行腹部手术的老年高血压患者80例,随机分为四组:A组、B组、C组、和D组,分别于麻醉诱导前静脉输注浓度为0.3 μg/kg、0.4μg/kg、0.5μg/kg和0.6μg/kg的右美托咪啶,依次记录患者输注右美托咪啶前(T0)、输注右美托咪啶后(T1)、气管插管即刻(T2)、气管插管后1 min(T3)、气管插管后3 min (T4)、气管插管后5 min(T5)的桡动脉收缩压(SAP)、舒张压(DAP)及心率(HR).结果 T2时刻A组SAP、DAP、HR分别为(129.8±12.9) mm Hg、(68.3±13.1)mm Hg、(65.4±13.6)次/min;B组SAP、DAP、HR分别为(127.2±13.0)mm Hg、(67.2±12.1)mm Hg、(65.1±13.1)次/min;C组SAP、DAP、HR分别为(141.8±15.1)mm Hg、(74.1±14.1)mm Hg、(70.4±13.1)次/min,D组SAP、DAP、HR分别为(141.1±13.1)mm Hg、(75.2±12.1)mm Hg、(71.2±11.0)次/min.T1及T2时刻四组三项指标均有所下降;T2时刻A组和B组三项指标显著下降(P＜0.05),C组及D组无显著下降;T3时刻A组及B组三项指标较T2时刻显著上升(P＜0.05),而C组及D组指标无显著改变;T4及T5时刻四组三项治疗较T0时刻均无显著改变(P＞0.05).结论 全麻诱导前静脉输注0.5 μg/kg或0.6 μg/kg浓度右美托咪啶可稳定老年高血压患者血流动力学波动,且安全性佳.
目的 分析不同劑量右美託咪啶對誘導插管期老年高血壓患者血流動力學的影響.方法 選擇在北京健宮醫院行腹部手術的老年高血壓患者80例,隨機分為四組:A組、B組、C組、和D組,分彆于痳醉誘導前靜脈輸註濃度為0.3 μg/kg、0.4μg/kg、0.5μg/kg和0.6μg/kg的右美託咪啶,依次記錄患者輸註右美託咪啶前(T0)、輸註右美託咪啶後(T1)、氣管插管即刻(T2)、氣管插管後1 min(T3)、氣管插管後3 min (T4)、氣管插管後5 min(T5)的橈動脈收縮壓(SAP)、舒張壓(DAP)及心率(HR).結果 T2時刻A組SAP、DAP、HR分彆為(129.8±12.9) mm Hg、(68.3±13.1)mm Hg、(65.4±13.6)次/min;B組SAP、DAP、HR分彆為(127.2±13.0)mm Hg、(67.2±12.1)mm Hg、(65.1±13.1)次/min;C組SAP、DAP、HR分彆為(141.8±15.1)mm Hg、(74.1±14.1)mm Hg、(70.4±13.1)次/min,D組SAP、DAP、HR分彆為(141.1±13.1)mm Hg、(75.2±12.1)mm Hg、(71.2±11.0)次/min.T1及T2時刻四組三項指標均有所下降;T2時刻A組和B組三項指標顯著下降(P＜0.05),C組及D組無顯著下降;T3時刻A組及B組三項指標較T2時刻顯著上升(P＜0.05),而C組及D組指標無顯著改變;T4及T5時刻四組三項治療較T0時刻均無顯著改變(P＞0.05).結論 全痳誘導前靜脈輸註0.5 μg/kg或0.6 μg/kg濃度右美託咪啶可穩定老年高血壓患者血流動力學波動,且安全性佳.
목적 분석불동제량우미탁미정대유도삽관기노년고혈압환자혈류동역학적영향.방법 선택재북경건궁의원행복부수술적노년고혈압환자80례,수궤분위사조:A조、B조、C조、화D조,분별우마취유도전정맥수주농도위0.3 μg/kg、0.4μg/kg、0.5μg/kg화0.6μg/kg적우미탁미정,의차기록환자수주우미탁미정전(T0)、수주우미탁미정후(T1)、기관삽관즉각(T2)、기관삽관후1 min(T3)、기관삽관후3 min (T4)、기관삽관후5 min(T5)적뇨동맥수축압(SAP)、서장압(DAP)급심솔(HR).결과 T2시각A조SAP、DAP、HR분별위(129.8±12.9) mm Hg、(68.3±13.1)mm Hg、(65.4±13.6)차/min;B조SAP、DAP、HR분별위(127.2±13.0)mm Hg、(67.2±12.1)mm Hg、(65.1±13.1)차/min;C조SAP、DAP、HR분별위(141.8±15.1)mm Hg、(74.1±14.1)mm Hg、(70.4±13.1)차/min,D조SAP、DAP、HR분별위(141.1±13.1)mm Hg、(75.2±12.1)mm Hg、(71.2±11.0)차/min.T1급T2시각사조삼항지표균유소하강;T2시각A조화B조삼항지표현저하강(P＜0.05),C조급D조무현저하강;T3시각A조급B조삼항지표교T2시각현저상승(P＜0.05),이C조급D조지표무현저개변;T4급T5시각사조삼항치료교T0시각균무현저개변(P＞0.05).결론 전마유도전정맥수주0.5 μg/kg혹0.6 μg/kg농도우미탁미정가은정노년고혈압환자혈류동역학파동,차안전성가.
Objective To analyze the effect of different doses of dexmedetomidine on the hemodynamics of elderly patients.Methods Eighty elderly patients treated with abdominal surgery in our hospital were selected and divided into four groups:group A (0.3μg/kg),group B (0.4μg/kg),group C (0.5μg/kg) and group D(0.6μg/kg).SAP,DAP and HR in six time points,which included before injection of dexmedetomidine,post injection of dexmedetomidine,tracheal intubation,1 min after tracheal intubation,3min after tracheal intubation,5min tracheal intubation,were analyzed.Results The levels of SAP,DAP and HR of the four groups at T1 and T2 declined.The levels of SAP,DAP and HR of group and group B at T2 significantly declined (P ＜ 0.05).The levels of SAP,DAP and HR of group A and group B at T3 were significantly higher than those of T2 (P ＜ 0.05).Conclusions The dose of dexmedetomidine in 0.5 μg/kg and 0.6 μg/kg can stabilize hemodynamic of elderly patients with hypertension.
