中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
9期
66-67
,共2页
HPV L1壳蛋白%宫颈上皮内瘤变%人乳头瘤病毒
HPV L1殼蛋白%宮頸上皮內瘤變%人乳頭瘤病毒
HPV L1각단백%궁경상피내류변%인유두류병독
HPV L1 capsid protein%Cervical intraepithelial neoplasia%Human papilloma virus
目的 探讨HPV L1壳蛋白在预测宫颈上皮内瘤变(CIN)转归中的意义.方法 选择液基细胞学(TCT)结果异常且高危型HPV HC2阳性的妇女144例,同时行HPV L1壳蛋白检测及宫颈活检,病理结果为诊断的金标准,并对CIN患者进行2年的随访.结果 HPV L1壳蛋白在CIN Ⅰ的阳性率最高(63.3％),大于CINⅡ和CINⅢ组,差异有统计学意义(P＜0.01),CINI Ⅰ和CINⅢ比较,差异未见统计学意义(P＞0.05).CINI组中HPVL1壳蛋白阳性者和HPVL1壳蛋白阴性者的自然消退率、病变进展率比较,差异有统计学意义(P＜0.05).CIN Ⅰ组中HPVL1壳蛋白预测病变进展的灵敏度为69.0％,特异度为71.4％,阳性预测值为93.5％,阴性预测值为27.8％.结论 HPV L1壳蛋白在判断CIN Ⅰ的预后情况中有显著的意义,为临床上处理CIN Ⅰ上提供指导意义.
目的 探討HPV L1殼蛋白在預測宮頸上皮內瘤變(CIN)轉歸中的意義.方法 選擇液基細胞學(TCT)結果異常且高危型HPV HC2暘性的婦女144例,同時行HPV L1殼蛋白檢測及宮頸活檢,病理結果為診斷的金標準,併對CIN患者進行2年的隨訪.結果 HPV L1殼蛋白在CIN Ⅰ的暘性率最高(63.3％),大于CINⅡ和CINⅢ組,差異有統計學意義(P＜0.01),CINI Ⅰ和CINⅢ比較,差異未見統計學意義(P＞0.05).CINI組中HPVL1殼蛋白暘性者和HPVL1殼蛋白陰性者的自然消退率、病變進展率比較,差異有統計學意義(P＜0.05).CIN Ⅰ組中HPVL1殼蛋白預測病變進展的靈敏度為69.0％,特異度為71.4％,暘性預測值為93.5％,陰性預測值為27.8％.結論 HPV L1殼蛋白在判斷CIN Ⅰ的預後情況中有顯著的意義,為臨床上處理CIN Ⅰ上提供指導意義.
목적 탐토HPV L1각단백재예측궁경상피내류변(CIN)전귀중적의의.방법 선택액기세포학(TCT)결과이상차고위형HPV HC2양성적부녀144례,동시행HPV L1각단백검측급궁경활검,병리결과위진단적금표준,병대CIN환자진행2년적수방.결과 HPV L1각단백재CIN Ⅰ적양성솔최고(63.3％),대우CINⅡ화CINⅢ조,차이유통계학의의(P＜0.01),CINI Ⅰ화CINⅢ비교,차이미견통계학의의(P＞0.05).CINI조중HPVL1각단백양성자화HPVL1각단백음성자적자연소퇴솔、병변진전솔비교,차이유통계학의의(P＜0.05).CIN Ⅰ조중HPVL1각단백예측병변진전적령민도위69.0％,특이도위71.4％,양성예측치위93.5％,음성예측치위27.8％.결론 HPV L1각단백재판단CIN Ⅰ적예후정황중유현저적의의,위림상상처리CIN Ⅰ상제공지도의의.
Objective To study the clinical value of HPV L1 capsid protein on predicting outcome of cervical intraepithelial neoplasia.Methods The HPV L1 caspid protein in cytologic specimens was detected by immunochemistry and cervical biopsy were performed in 144 patients whose HPV DNA detection was positive and TCT detection was abnormal.All diagnosis were confirmed in histology.The patients with CIN were followed up for at least 2 years.Results The positive rate of immunostaining reaction for HPV L1 capsid protein of CIN Ⅰ was 63.3％,which was higher than CIN Ⅰ and CIN Ⅲ (P ＜0.01).However,the differences of positive rates of CIN Ⅱ and CIN Ⅲ in the two groups were not statistically significant(P ＞ 0.05).The spontaneous regression rate of HPV L1 positive CINI patients was higher than that of HPV L1 negative CINI patients (P ＜ 0.05).The same as the progression rate (P ＜0.05).The sensitivity,specificity,positive predictive value and negative predictive value for the HPV L1 predicting outcome of CINI were 69.0％,71.4％,93.5％ and 27.8％,respectively.Conclusions The value of HPV L1 in predicting outcome of CINI is significant.Immunocytochemical detection of HPV L1 capsid protein may provide guidance for treatment CINI.
