CAJ | 학술논문

目的观察鞘内化疗联合放疗治疗脑转移瘤的疗效.方法经影像学及病理学诊断为脑转移瘤患者40例,随机分为治疗组15例,予恩度15 mg+甲氨蝶呤15 mg+地塞米松5 mg鞘内化疗联合放疗治疗,对照组25例仅给予放疗,比较两组1年复发率、无复发生存时间、治疗前后患者生活质量变化及药物不良反应.结果治疗组与对照组患者1年复发率、无复发生存时间、治疗前后患者生活质量变化等方面比较差异有统计学意义(P＜0.05).主要不良反应有头昏、骨髓抑制,腹痛、腹胀,腰痛,脱发等.结论对脑转移瘤采用鞘内化疗联合放疗能有效提高生存质量、延长寿命,其不良反应小.
목적 관찰초내화료연합방료치료뇌전이류적료효.방법 경영상학급병이학진단위뇌전이류환자40례,수궤분위치료조15례,여은도15 mg+갑안접령15 mg+지새미송5 mg초내화료연합방료치료,대조조25례부급여방료,비교량조1년복발솔、무복발생존시간、치료전후환자생활질량변화급약물불량반응.결과 치료조여대조조환자1년복발솔、무복발생존시간、치료전후환자생활질량변화등방면비교차이유통계학의의(P＜0.05).주요불량반응유두혼、골수억제,복통、복창,요통,탈발등.결론 대뇌전이류채용초내화료연합방료능유효제고생존질량、연장수명,기불량반응소.
Objective To observe the effect of intrathecal chemotherapy combined with radiotherapy on brain metastases tumor.Methods Forty patients were diagnosed with brain metastatic tumor by imaging and pathology,and were randomly divided into treatment group (15 cases) and control group (25 cases),and received Endostar 15 mg + methotrexate 15 mg + dexamethasone 5 mg intrathecal chemotherapy combined with radiation therapy in treatment group.Control group only had radiation therapy.The one year recurrence rate,relapse-free survival time and quality of life changes of the patients before and after treatment and drug adverse reaction were compared between the two groups.Results The one year recurrence rate,relapse-free survival time and quality of life changes of the patients before and after treatment had statistically significant differences between the two groups (P ＜ 0.05).Main side reactions were dizziness,bone marrow suppression,abdominal pain,abdominal distension,lumbago,hair loss,etc.Conclusions Intrathecal chemotherapy combined with radiotherapy for cerebral metastases is effective to improve the quality of survival,prolong life,its side reaction is small.