中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
10期
5-6
,共2页
多烯磷脂酰胆碱%酒精性肝病%疗效
多烯燐脂酰膽堿%酒精性肝病%療效
다희린지선담감%주정성간병%료효
Polyene phosphatidyl choline%Alcoholic liver disease%Effect
目的 探讨在酒精性肝病治疗中应用多烯磷脂酰胆碱的临床效果及应用价值.方法 回顾性分析2012年9月至2013年9月河南平煤神马医疗集团总医院肝病科室收治的82例酒精性肝病患者的临床资料,参照数字对比法将82例患者分为对照组和实验组,对照组给予戒酒、维生素、甘草酸二胺等常规治疗,实验组在此基础上注射多烯磷脂酰胆碱液治疗,观察两组治疗4周后肝功能指标改善及治疗效果.结果 两组治疗满1个疗程后总胆红素、碱性磷酸酶、谷丙转氨酶、谷氨酰转肽酶四项主要肝功能指标水平均较治疗前明显改善(P＜0.05),但实验组上述几项指标改善幅度明显大于对照组(P＜0.05).实验组治疗总有效率(85.7％)明显高于对照组(72.5％),差异有统计学意义(P＜0.05).结论 多烯磷脂酰胆碱具有良好的抗纤维化作用,配合纤维素、甘草酸二胺等用药能显著改善酒精肝功能状况,提高治疗效果,安全可靠,值得临床加以研究推广.
目的 探討在酒精性肝病治療中應用多烯燐脂酰膽堿的臨床效果及應用價值.方法 迴顧性分析2012年9月至2013年9月河南平煤神馬醫療集糰總醫院肝病科室收治的82例酒精性肝病患者的臨床資料,參照數字對比法將82例患者分為對照組和實驗組,對照組給予戒酒、維生素、甘草痠二胺等常規治療,實驗組在此基礎上註射多烯燐脂酰膽堿液治療,觀察兩組治療4週後肝功能指標改善及治療效果.結果 兩組治療滿1箇療程後總膽紅素、堿性燐痠酶、穀丙轉氨酶、穀氨酰轉肽酶四項主要肝功能指標水平均較治療前明顯改善(P＜0.05),但實驗組上述幾項指標改善幅度明顯大于對照組(P＜0.05).實驗組治療總有效率(85.7％)明顯高于對照組(72.5％),差異有統計學意義(P＜0.05).結論 多烯燐脂酰膽堿具有良好的抗纖維化作用,配閤纖維素、甘草痠二胺等用藥能顯著改善酒精肝功能狀況,提高治療效果,安全可靠,值得臨床加以研究推廣.
목적 탐토재주정성간병치료중응용다희린지선담감적림상효과급응용개치.방법 회고성분석2012년9월지2013년9월하남평매신마의료집단총의원간병과실수치적82례주정성간병환자적림상자료,삼조수자대비법장82례환자분위대조조화실험조,대조조급여계주、유생소、감초산이알등상규치료,실험조재차기출상주사다희린지선담감액치료,관찰량조치료4주후간공능지표개선급치료효과.결과 량조치료만1개료정후총담홍소、감성린산매、곡병전안매、곡안선전태매사항주요간공능지표수평균교치료전명현개선(P＜0.05),단실험조상술궤항지표개선폭도명현대우대조조(P＜0.05).실험조치료총유효솔(85.7％)명현고우대조조(72.5％),차이유통계학의의(P＜0.05).결론 다희린지선담감구유량호적항섬유화작용,배합섬유소、감초산이알등용약능현저개선주정간공능상황,제고치료효과,안전가고,치득림상가이연구추엄.
Objective To investigate the clinical effect of polyene phosphatidylcholine on alcoholic liver disease.Methods A retrospective analysis was conducted in terms of 82 patients with alcoholic liver disease who were admitted to the hospital from September 2012 to September 2013.The 82 cases were divided into control group and experimental group.The control group was given temperance,vitamins,diammonium glycyrrhizinate and some other conventional treatment,and on this basis the experimental group was given polyene phosphatidylcholine injection.The improvements of liver function after 4 weeks of treatment were observed.Results After 4 weeks of treatment,the levels of TBIL,ALT,AST and γ-GT,which were key indicators of liver function,were significantly decreased (P ＜ 0.05).What is more,the differences of indicators above in experimental group were more significantly than that of control group((P ＜0.05).The effective rate in experimental group(85.7％) was significantly higher than that of control group(72.5％,P ＜ 0.05).Conclusions Polyene phosphatidylcholine is effective in anti-fibrosis,and it can well improve alcoholic liver disease with fibrin and diammonium glycyrrhizinate,which is therefore worthy of clinical promotion.
