中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
10期
17-19
,共3页
癫痫%新诊断%保留率%日常生活能力
癲癇%新診斷%保留率%日常生活能力
전간%신진단%보류솔%일상생활능력
Patients with epilepsy%Newly diagnosed%Retention rate%Activities of daily living
目的 比较几种抗癫痫药物对新诊断癫痫患者的总有效率和保留率.方法 选择2012年1月至2013年5月在晋城市人民医院神经内科就诊的癫痫患者89例.以单药治疗为原则,根据病情采用联合治疗,观察3、6、9、12个月治疗期内癫痫发作频率相对规范治疗前下降的百分比,比较其总有效率,并分析停药原因.对每组患者的日常生活能力进行量表评定和分析.结果 三种抗癫痫药控制癫痫的疗效基本一致,总有效率为79.3％～87％,差异未见统计学意义(P＞0.05).三种药物的3、6、9、12个月保留率分别为:丙戊酸钠89.2％、81.1％、81.1％、75.7％,卡马西平86.2％、79.3％、72.4％、72.4％,拉莫三嗪91.3％、91.3％、87.0％、87.0％.每季度各组保留率比较差异未见统计学意义(P＞0.05).停药或换药的主要原因是癫痫控制效果差(15例,75％),其次是不良反应(4例,20％).对各组患者治疗前和治疗后12个月日常生活能力量表进行评定,拉莫三嗪组最高,差异有统计学意义(P＜0.05).结论 三种抗癫痫药的有效性及保留率比较差异未见统计学意义(P＞0.05),停药原因主要为药物疗效不佳和不良反应,拉莫三嗪可改善患者治疗12个月时日常生活能力.
目的 比較幾種抗癲癇藥物對新診斷癲癇患者的總有效率和保留率.方法 選擇2012年1月至2013年5月在晉城市人民醫院神經內科就診的癲癇患者89例.以單藥治療為原則,根據病情採用聯閤治療,觀察3、6、9、12箇月治療期內癲癇髮作頻率相對規範治療前下降的百分比,比較其總有效率,併分析停藥原因.對每組患者的日常生活能力進行量錶評定和分析.結果 三種抗癲癇藥控製癲癇的療效基本一緻,總有效率為79.3％～87％,差異未見統計學意義(P＞0.05).三種藥物的3、6、9、12箇月保留率分彆為:丙戊痠鈉89.2％、81.1％、81.1％、75.7％,卡馬西平86.2％、79.3％、72.4％、72.4％,拉莫三嗪91.3％、91.3％、87.0％、87.0％.每季度各組保留率比較差異未見統計學意義(P＞0.05).停藥或換藥的主要原因是癲癇控製效果差(15例,75％),其次是不良反應(4例,20％).對各組患者治療前和治療後12箇月日常生活能力量錶進行評定,拉莫三嗪組最高,差異有統計學意義(P＜0.05).結論 三種抗癲癇藥的有效性及保留率比較差異未見統計學意義(P＞0.05),停藥原因主要為藥物療效不佳和不良反應,拉莫三嗪可改善患者治療12箇月時日常生活能力.
목적 비교궤충항전간약물대신진단전간환자적총유효솔화보류솔.방법 선택2012년1월지2013년5월재진성시인민의원신경내과취진적전간환자89례.이단약치료위원칙,근거병정채용연합치료,관찰3、6、9、12개월치료기내전간발작빈솔상대규범치료전하강적백분비,비교기총유효솔,병분석정약원인.대매조환자적일상생활능력진행량표평정화분석.결과 삼충항전간약공제전간적료효기본일치,총유효솔위79.3％～87％,차이미견통계학의의(P＞0.05).삼충약물적3、6、9、12개월보류솔분별위:병무산납89.2％、81.1％、81.1％、75.7％,잡마서평86.2％、79.3％、72.4％、72.4％,랍막삼진91.3％、91.3％、87.0％、87.0％.매계도각조보류솔비교차이미견통계학의의(P＞0.05).정약혹환약적주요원인시전간공제효과차(15례,75％),기차시불량반응(4례,20％).대각조환자치료전화치료후12개월일상생활능역량표진행평정,랍막삼진조최고,차이유통계학의의(P＜0.05).결론 삼충항전간약적유효성급보류솔비교차이미견통계학의의(P＞0.05),정약원인주요위약물료효불가화불량반응,랍막삼진가개선환자치료12개월시일상생활능력.
Objective To investigate the total efficiency and retention rate of different drug treatment for newly diagnosed patients with epilepsy.Methods Eighty-nine patients with epilepsy in Jincheng People's Hospital from January 2012 to May 2013 were selected,treated by monotherapy principle and using combination therapy according to the disease.Compared before the standard treatment,the percentage decline of epileptic seizure frequency in 3,6,9,12 months was observed,and the total efficiency,reason for discontinuation,activities of daily living of patients were analyzed.Results Three kinds of anti-epileptic drugs to control epilepsy had basically the same effect and the total effective rate was 79.3％ ～ 87％ (P ＞ 0.05).The 3,6,9,12-month retention rates of three drugs:sodium valproate 89.2％,81.1％,81.1％,75.7％ ; carbamazepine 86.2％,79.3％,72.4％,72.4％,and Lamotrigine 91.3％,91.3％,87.0％,87.0％.Retention rate in each group was no significant difference on a quarterly basis.The main reason of the withdrawal or dressing were poor seizure control(15 cases,75％) ; followed by adverse reactions(4 cases,20％).For each group of patients before and after treatment and 12 months were assessed daily living scale,the highest lamotrigine group (P ＜ 0.05).Conclusions Effectiveness and retention rates of three kinds of antiepileptic drugs has no significant difference between the pros and cons,the main reason of the discontinuation are poor drug efficacy and adverse effects.Lamotrigine can improve activities of daily living of patients in treatment for 12 months.
