CAJ | 학술논문

目的分析腰围身高比值(WHtR)对新发空腹血糖受损(IFG)及糖尿病的影响.方法本研究采用前瞻性队列研究方法,以参与开滦集团有限责任公司2006 ～ 2007年度健康体检时空腹血糖(FPG) ＜5.6 mmol/L且无糖尿病病史、同时于2012 ～2013年度进行体检且腰围、身高及FPG数据均完整的46 238名对象作为观察队列,依据基线WHtR四分位数分为4组,比较4组间IFG和糖尿病的发生率.用多因素logistic回归分析影响新发IFG和糖尿病的因素.结果 (1) IFG和糖尿病的发生率分别为46.88/1 000人年和6.79/1000人年,且随基线WHtR增加,新发IFG和糖尿病的发生率均逐渐升高,第一、二、三、四分位组IFG发生率分别为10.37/1000人年、9.77/1000人年、13.10/1 000人年、13.64/1 000人年,糖尿病的发生率分别为0.95/1000人年、1.11/1000人年、1.83/1000人年、2.91/1000人年.(2)经多因素logistic回归分析显示,与第一分位组比较,第二、三、四分位组新发IFG的风险增加,RR值分别为1.337、1.560、1.839,第二、三、四分位组新发糖尿病的风险也增加,RR值分别为1.669、2.335、4.170.结论 WHtR增大预示IFG和糖尿病的发病风险增加.
목적 분석요위신고비치(WHtR)대신발공복혈당수손(IFG)급당뇨병적영향.방법 본연구채용전첨성대렬연구방법,이삼여개란집단유한책임공사2006 ～ 2007년도건강체검시공복혈당(FPG) ＜5.6 mmol/L차무당뇨병병사、동시우2012 ～2013년도진행체검차요위、신고급FPG수거균완정적46 238명대상작위관찰대렬,의거기선WHtR사분위수분위4조,비교4조간IFG화당뇨병적발생솔.용다인소logistic회귀분석영향신발IFG화당뇨병적인소.결과 (1) IFG화당뇨병적발생솔분별위46.88/1 000인년화6.79/1000인년,차수기선WHtR증가,신발IFG화당뇨병적발생솔균축점승고,제일、이、삼、사분위조IFG발생솔분별위10.37/1000인년、9.77/1000인년、13.10/1 000인년、13.64/1 000인년,당뇨병적발생솔분별위0.95/1000인년、1.11/1000인년、1.83/1000인년、2.91/1000인년.(2)경다인소logistic회귀분석현시,여제일분위조비교,제이、삼、사분위조신발IFG적풍험증가,RR치분별위1.337、1.560、1.839,제이、삼、사분위조신발당뇨병적풍험야증가,RR치분별위1.669、2.335、4.170.결론 WHtR증대예시IFG화당뇨병적발병풍험증가.
Objective To analyze the impact of waist-to-height ratio (WHtR) on newly onset of impaired fasting glucose(IFG) and diabetes mellitus.Methods A total of 46 238 subjects were enrolled as the observation cohort.Their fasting plasma glucose (FPG) was below 5.6 mmol/L and there was no history of diabetes during the 2006-2007 health examination.Complete data of waist circumference,body height,and FPG were made in the 2012-2013 health examination.According to the baseline WHtR quartile,the observed cohort was divided into four groups,in which the incidences of newly onset of IFG and diabetes were compared.Multiple logistic regression analysis was used to analyze the influencing factor of newly onset of IFG and diabetes.Results (1) The incidences of newly onset IFG and diabetes were 46.88 per 1 000 person-years and 6.79 per 1 000 person-years respectively.Along with increasing WHtR in the 4 quartile groups,the incidences of newly onset IFG were progressively increased,being 10.37,9.77,13.10,and 13.64 per 1 000 person-years,respectively.The incidences of newly onset diabetes were 0.95,1.11,1.83,and 2.91 per 1 000 person-years in the 4 quartile groups,respectively.(2) Multiple logistic regression analysis showed that compared with the first quartile group,the second,third and forth quartile groups had increased risks of newly onset IFG,the RR value was 1.337,1.560,and 1.839,respectively.The second,third,and forth quartile groups had also increased risks of newly onset diabetes,the RR value was 1.669,2.335,and 4.170,respectively.Conclusion The incidences of newly onset IFG and diabetes are increased along with the increasing WHtR.