中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2015年
5期
297-301
,共5页
周稚辉%范伟伟%郎淼杰%王彦亮
週稚輝%範偉偉%郎淼傑%王彥亮
주치휘%범위위%랑묘걸%왕언량
骨坏死,放射性%下颌骨%超声疗法
骨壞死,放射性%下頜骨%超聲療法
골배사,방사성%하합골%초성요법
Osteoradionecrosis%Mandible%Ultrasonic therapy
目的 证实低强度超声对颌骨放射性骨坏死(osteoradionecrosis of jaws,ORNJ)的预防作用.方法 25只实验犬按照随机数字表法分为实验组(20只)和空白对照组(5只).实验组接受X射线照射后,又分为实验A组(10只)和实验B组(10只);空白对照组不接受射线照射.放疗结束后1个月,拔除所有动物下颌双侧第四前磨牙,实验B组立即予以低强度超声处理20 d,实验A组和空白对照组不做处理.拔牙后2个月,确定ORNJ的形成并比较实验A、B组ORNJ的发生率.通过影像学观察和病理学检测比较实验A、B组间照射区下颌骨骨质变化.结果 实验A、B组所有动物均发生ORNJ.影像学观察尽管实验A组和实验B组照射区骨密度均低于空白对照组,但实验B组骨密度明显好于实验A组.微型CT显示实验B组骨小梁的骨体积分数、骨小梁厚度、骨表面积和骨体积的比值和骨小梁数量分别为(0.187±0.029)％、(0.160±O.039) μm、(12.536±2.558)/mm、(1.227±0.192)/mm,均显著大于实验A组相对应值[分别为(0.103±0.014)％、(0.069±0.013) μm、(5.598±0.731)/mm、(0.522±0.064)/mm](P＜0.05).微血管密度检测实验B组大于实验A组.结论 应用低强度超声无法阻止ORNJ的形成,但能明显改善ORNJ的症状.
目的 證實低彊度超聲對頜骨放射性骨壞死(osteoradionecrosis of jaws,ORNJ)的預防作用.方法 25隻實驗犬按照隨機數字錶法分為實驗組(20隻)和空白對照組(5隻).實驗組接受X射線照射後,又分為實驗A組(10隻)和實驗B組(10隻);空白對照組不接受射線照射.放療結束後1箇月,拔除所有動物下頜雙側第四前磨牙,實驗B組立即予以低彊度超聲處理20 d,實驗A組和空白對照組不做處理.拔牙後2箇月,確定ORNJ的形成併比較實驗A、B組ORNJ的髮生率.通過影像學觀察和病理學檢測比較實驗A、B組間照射區下頜骨骨質變化.結果 實驗A、B組所有動物均髮生ORNJ.影像學觀察儘管實驗A組和實驗B組照射區骨密度均低于空白對照組,但實驗B組骨密度明顯好于實驗A組.微型CT顯示實驗B組骨小樑的骨體積分數、骨小樑厚度、骨錶麵積和骨體積的比值和骨小樑數量分彆為(0.187±0.029)％、(0.160±O.039) μm、(12.536±2.558)/mm、(1.227±0.192)/mm,均顯著大于實驗A組相對應值[分彆為(0.103±0.014)％、(0.069±0.013) μm、(5.598±0.731)/mm、(0.522±0.064)/mm](P＜0.05).微血管密度檢測實驗B組大于實驗A組.結論 應用低彊度超聲無法阻止ORNJ的形成,但能明顯改善ORNJ的癥狀.
목적 증실저강도초성대합골방사성골배사(osteoradionecrosis of jaws,ORNJ)적예방작용.방법 25지실험견안조수궤수자표법분위실험조(20지)화공백대조조(5지).실험조접수X사선조사후,우분위실험A조(10지)화실험B조(10지);공백대조조불접수사선조사.방료결속후1개월,발제소유동물하합쌍측제사전마아,실험B조립즉여이저강도초성처리20 d,실험A조화공백대조조불주처리.발아후2개월,학정ORNJ적형성병비교실험A、B조ORNJ적발생솔.통과영상학관찰화병이학검측비교실험A、B조간조사구하합골골질변화.결과 실험A、B조소유동물균발생ORNJ.영상학관찰진관실험A조화실험B조조사구골밀도균저우공백대조조,단실험B조골밀도명현호우실험A조.미형CT현시실험B조골소량적골체적분수、골소량후도、골표면적화골체적적비치화골소량수량분별위(0.187±0.029)％、(0.160±O.039) μm、(12.536±2.558)/mm、(1.227±0.192)/mm,균현저대우실험A조상대응치[분별위(0.103±0.014)％、(0.069±0.013) μm、(5.598±0.731)/mm、(0.522±0.064)/mm](P＜0.05).미혈관밀도검측실험B조대우실험A조.결론 응용저강도초성무법조지ORNJ적형성,단능명현개선ORNJ적증상.
Objective To investigate the preventive effect of low-intensity ultrasound on osteoradionecrosis of jaws (ORNJ).Methods Twenty-five canines were randomly divided into experimental group (n=20)and control group (n=5).The canines in experimental group received radiation exposure,and then were randomly subdivided into group A (n=10)and group B (n=10).Control group did not undergo radiotherapy.One month after radiotherapy,the fourth mandibular premolars of all animals were extracted.Group B was immediately treated by low-intensity ultrasound for twenty days,group A and control group did not receive any treatment.Two months after tooth extraction,the formation of ORNJ was determined and the occurrence rate of ORNJ was compared between group A and B.The microstructure of the mandible and changes in microvascular density in group A and B were evaluated and compared with those of control group.Results All animals in group B and group A developed ORNJ after prophylactic ultrasound was applied for twenty days.Although the imaging examination of bony density of group A and B were lower than normal animals in control group,bone density in group B was significantly better than group A.Micro-CT showed that the trabecular bone volume fraction,trabecular thickness,bone surface/bone volume and trabecular number in group B were respectively (0.187±0.029)％,(0.160±0.039) μm,(12.536±2.558)/mm,(1.227± 0.192)/mm,which were all greater than group A [(0.103±0.014)％,(0.069±0.013) μm,(5.598±0.731)/mm,(0.522 ± 0.064)/mm)] (P＜0.05).Conclusions Although the preventive application of low intensity ultrasound can not prevent the formation of ORNJ,but can significantly improve the symptoms of ORNJ.
