国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
10期
1436-1438
,共3页
电化学发光法%游离前列腺抗原%前列腺癌%前列腺增生
電化學髮光法%遊離前列腺抗原%前列腺癌%前列腺增生
전화학발광법%유리전렬선항원%전렬선암%전렬선증생
Electrochemical luminescence method%Free prostate antigen%Prostate cancer%Benign prostatic hyperplasia
目的 探讨电化学发光法检测游离前列腺抗原的效果.方法 选取正常体检者80例.经活检确诊的患有前列腺疾病的患者214例,其中前列腺癌(PCa)79例,前列腺增生(BPH)71例,前列腺炎(BP)64例.采用电化学发光法(ECLA)检测各组患者血清总前列腺特异性抗原(tPSA)、与游离前列腺特异性抗原(fPSA)水平并计算其比值f/tPSA.以fPSA＜1 ng/ml为临界点,分析四组患者在fPSA各水平的符合率差异,并计算上述各区间范围内FPSA诊断的灵敏度、特异度、阳性预测值、阴性预测值.结果 前列腺炎组、前列腺增生组患者游离前列腺抗原fPSA、总前列腺抗原tPSA升高,二者比值fPSA/tPSA降低(P＜0.05).前列腺癌组的fPSA、tPSA升高更加明显,fPSA/tPSA值也显著降低(P＜0.05).正常组与前列腺癌组符合率均为100％,前列腺炎组为93.67％,前列腺增生组为95.77％.总符合率为94.72％.结论 电化学发光法检测游离前列腺抗原灵敏度高,特异性强,适用于临床诊断、鉴别前列腺疾病,值得推广.
目的 探討電化學髮光法檢測遊離前列腺抗原的效果.方法 選取正常體檢者80例.經活檢確診的患有前列腺疾病的患者214例,其中前列腺癌(PCa)79例,前列腺增生(BPH)71例,前列腺炎(BP)64例.採用電化學髮光法(ECLA)檢測各組患者血清總前列腺特異性抗原(tPSA)、與遊離前列腺特異性抗原(fPSA)水平併計算其比值f/tPSA.以fPSA＜1 ng/ml為臨界點,分析四組患者在fPSA各水平的符閤率差異,併計算上述各區間範圍內FPSA診斷的靈敏度、特異度、暘性預測值、陰性預測值.結果 前列腺炎組、前列腺增生組患者遊離前列腺抗原fPSA、總前列腺抗原tPSA升高,二者比值fPSA/tPSA降低(P＜0.05).前列腺癌組的fPSA、tPSA升高更加明顯,fPSA/tPSA值也顯著降低(P＜0.05).正常組與前列腺癌組符閤率均為100％,前列腺炎組為93.67％,前列腺增生組為95.77％.總符閤率為94.72％.結論 電化學髮光法檢測遊離前列腺抗原靈敏度高,特異性彊,適用于臨床診斷、鑒彆前列腺疾病,值得推廣.
목적 탐토전화학발광법검측유리전렬선항원적효과.방법 선취정상체검자80례.경활검학진적환유전렬선질병적환자214례,기중전렬선암(PCa)79례,전렬선증생(BPH)71례,전렬선염(BP)64례.채용전화학발광법(ECLA)검측각조환자혈청총전렬선특이성항원(tPSA)、여유리전렬선특이성항원(fPSA)수평병계산기비치f/tPSA.이fPSA＜1 ng/ml위림계점,분석사조환자재fPSA각수평적부합솔차이,병계산상술각구간범위내FPSA진단적령민도、특이도、양성예측치、음성예측치.결과 전렬선염조、전렬선증생조환자유리전렬선항원fPSA、총전렬선항원tPSA승고,이자비치fPSA/tPSA강저(P＜0.05).전렬선암조적fPSA、tPSA승고경가명현,fPSA/tPSA치야현저강저(P＜0.05).정상조여전렬선암조부합솔균위100％,전렬선염조위93.67％,전렬선증생조위95.77％.총부합솔위94.72％.결론 전화학발광법검측유리전렬선항원령민도고,특이성강,괄용우림상진단、감별전렬선질병,치득추엄.
Objective To study the effect of electrochemical luminescence method to detect free prostate antigen.Methods 80 cases of normal physical examination,214 patients with prostate disease diagnosed by biopsy [79 cases of prostate cancer (PCa),71 cases of benign prostatic hyperplasia (BPH),64 cases of prostatitis (BP)] were selected.Detected the levels of serum total prostate specific antigen (tPSA) and free prostate specific antigen (fPSA) of all subjects by electrochemical luminescence (ECLA),and calculated the ratio of f/tPSA.With fPSA ＜1 ng/ml as critical point,analyzed fPSA coincidence rate of various levels of four groups,and calculated fPSA diagnostic sensitivity,specific,positive predictive value,negative predictive value during different interval ranges.Results fPSA,tPSA of BP group and BPH group rose,fPSA/tPSA lowered (P＜0.05).fPSA,tPSA of PCa group rose more significantly,fPSA/tPSA lowered more significantly (P＜0.05).The coincidence rate of normal group and PCa group were both 100％,that of BP group was 93.67％,that of BPH group was 95.77％,with the total coincidence rate of 94.72％.Conclusions Electrochemical luminescence method to detect free prostate antigen has high sensitivity and strong specificity,which is suitable for clinical diagnosis and differential diagnosis of prostate disease,worthy of clinical promotion.
