中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
7期
55-57
,共3页
性别%胃肠道肿瘤%化疗%不良反应
性彆%胃腸道腫瘤%化療%不良反應
성별%위장도종류%화료%불량반응
Gender%Gastrointestinal tumor%Chemotherapy%Adverse reaction
目的 观察不同性别胃肠道肿瘤患者在化疗中不良反应的特点.方法 选取行FOLFOX4化疗方案治疗的79例胃肠道肿瘤患者,其中女38例,男41例.按性别分组,观察整个化疗过程中不良反应的情况.结果 女性与男性恶心、呕吐比较差异有统计学意义(P =0.007);腹泻(P=0.585)、口腔黏膜炎(P=0.393)、脱发(P=0.269)、神经系统毒性(P=0.212)、心脏节律改变(P=0.618)、皮疹(P=0.309)、白细胞减少(P =0.255)、血红蛋白减少(P=0.231)、血小板减少(P=0.194)、丙氨酸氨基转移酶升高(P=0.585)、肌酐升高(P=0.514)等不良反应比较差异未见统计学意义.结论 女性与男性相比,化疗中恶心、呕吐的发生率高,程度重.
目的 觀察不同性彆胃腸道腫瘤患者在化療中不良反應的特點.方法 選取行FOLFOX4化療方案治療的79例胃腸道腫瘤患者,其中女38例,男41例.按性彆分組,觀察整箇化療過程中不良反應的情況.結果 女性與男性噁心、嘔吐比較差異有統計學意義(P =0.007);腹瀉(P=0.585)、口腔黏膜炎(P=0.393)、脫髮(P=0.269)、神經繫統毒性(P=0.212)、心髒節律改變(P=0.618)、皮疹(P=0.309)、白細胞減少(P =0.255)、血紅蛋白減少(P=0.231)、血小闆減少(P=0.194)、丙氨痠氨基轉移酶升高(P=0.585)、肌酐升高(P=0.514)等不良反應比較差異未見統計學意義.結論 女性與男性相比,化療中噁心、嘔吐的髮生率高,程度重.
목적 관찰불동성별위장도종류환자재화료중불량반응적특점.방법 선취행FOLFOX4화료방안치료적79례위장도종류환자,기중녀38례,남41례.안성별분조,관찰정개화료과정중불량반응적정황.결과 녀성여남성악심、구토비교차이유통계학의의(P =0.007);복사(P=0.585)、구강점막염(P=0.393)、탈발(P=0.269)、신경계통독성(P=0.212)、심장절률개변(P=0.618)、피진(P=0.309)、백세포감소(P =0.255)、혈홍단백감소(P=0.231)、혈소판감소(P=0.194)、병안산안기전이매승고(P=0.585)、기항승고(P=0.514)등불량반응비교차이미견통계학의의.결론 녀성여남성상비,화료중악심、구토적발생솔고,정도중.
Objective To investigate the characteristics of adverse reactions of chemotherapy in different gender patients with gastrointestinal tumor.Methods Seventy-nine cases of gastrointestinal cancer received FOLFOX4 chemotherapy,including 38 cases of female,41 cases of male.Grouped by gender,the adverse reactions of chemotherapy in the whole process were observed.Results Females compared with males,the difference of nausea and vomiting was statistically significant (P =0.007);diarrhea (P =0.585),oral mucositis (P =0.393),alopecia (P =0.269),nervous system toxicity (P =0.212),heart rhythm changing (P =0.618),rash (P =0.309),white blood cells decreasing (P =0.255),hemoglobin decreasing (P =0.231),thrombocytopenia decreasing (P =0.194),alanine aminotransferase increasing (P =0.585),creatinine increasing (P =0.514) had no significant difference between the other adverse reactions.Conclusions Compared with men and women,the incidence of nausea,vomiting is high,and is severe.
