中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
8期
1-4
,共4页
局部晚期宫颈癌%新辅助化疗%Ki-67%P糖蛋白
跼部晚期宮頸癌%新輔助化療%Ki-67%P糖蛋白
국부만기궁경암%신보조화료%Ki-67%P당단백
Locally advanced cervical cancer%Neoadjuvant chemotherapy%Ki-67%P-gp
目的 分析局部晚期宫颈癌(LACC)组织中Ki-67、P糖蛋白(P-gp)的表达与新辅助化疗(NACT)疗效的关系,探讨二者的共表达性及临床病理意义.方法 运用免疫组化法对53例LACC患者进行NACT前Ki-67、P-gp的表达量进行检测.结果 53例LACC患者中有效32例(60.4％).NACT疗效与Ki-67、P-gp的表达显著相关(P=0.006、0.029),Logistic回归显示Ki-67表达量越高、P-gp表达量越低,NACT越敏感(β=2.163、-3.39).Spearman分析显示尚不能认为Ki-67与P-gp相关(P =0.325),且尚不能认为二者的共表达性与深肌层浸润、盆腔淋巴结转移相关(P=0.242、0.871).结论 NACT可用于LACC的治疗,Ki-67、P-gp可作为预测NACT疗效的指标.
目的 分析跼部晚期宮頸癌(LACC)組織中Ki-67、P糖蛋白(P-gp)的錶達與新輔助化療(NACT)療效的關繫,探討二者的共錶達性及臨床病理意義.方法 運用免疫組化法對53例LACC患者進行NACT前Ki-67、P-gp的錶達量進行檢測.結果 53例LACC患者中有效32例(60.4％).NACT療效與Ki-67、P-gp的錶達顯著相關(P=0.006、0.029),Logistic迴歸顯示Ki-67錶達量越高、P-gp錶達量越低,NACT越敏感(β=2.163、-3.39).Spearman分析顯示尚不能認為Ki-67與P-gp相關(P =0.325),且尚不能認為二者的共錶達性與深肌層浸潤、盆腔淋巴結轉移相關(P=0.242、0.871).結論 NACT可用于LACC的治療,Ki-67、P-gp可作為預測NACT療效的指標.
목적 분석국부만기궁경암(LACC)조직중Ki-67、P당단백(P-gp)적표체여신보조화료(NACT)료효적관계,탐토이자적공표체성급림상병리의의.방법 운용면역조화법대53례LACC환자진행NACT전Ki-67、P-gp적표체량진행검측.결과 53례LACC환자중유효32례(60.4％).NACT료효여Ki-67、P-gp적표체현저상관(P=0.006、0.029),Logistic회귀현시Ki-67표체량월고、P-gp표체량월저,NACT월민감(β=2.163、-3.39).Spearman분석현시상불능인위Ki-67여P-gp상관(P =0.325),차상불능인위이자적공표체성여심기층침윤、분강림파결전이상관(P=0.242、0.871).결론 NACT가용우LACC적치료,Ki-67、P-gp가작위예측NACT료효적지표.
Objective To study the correlation between expression of Ki-67,P-gp and effect of neoadjuvant chemotherapy(NACT) in locally advanced cervical cancer(LACC),and to investigate coexpression of Ki-67,P-gp and its siginificance.Methods Fifty-three cases of LACC biopsy specimens before treatment were collected.Expression of Ki-67 and P-gp was analyzed with the technique of immunohistochemical staining.Results Thirty-two cases were effective among the total cases(60.4％).There was siginificant correlation of the expression of Ki-67,P-gp with the effect of NACT (P =0.006,0.029).High expression of Ki-67 and low expression of P-gp were positive factors for effect of NACT through results of the logistic regression(β =2.163,-3.39).The results of the spearman corelations showed that there was no correlation of the expression of Ki-67 with P-gp(P =0.325).Co-expression of Ki-67,P-gp showed no relationship with deep stromal invasion and pelvic lymph node metastasis (P =0.242,0.871).Conclusions NACT can be applied to treatment of LACC,and the expression of Ki-67 and P-gp are indicators of predicting the effect of NACT.
