CAJ | 학술논문

目的探讨重症肺炎患者纤溶系统功能和炎症指标的变化及临床意义.方法选取2013年6月至2014年6月期间入住郑州大学第一附属医院RICU的40例重症肺炎患者与本院体检中心同期40例健康体检者作为研究对象,分别测定其血清中的纤维蛋白原降解产物(FDP)、D-二聚体(D-D)、降钙素原(PCT)、C-反应蛋白(CRP)、血沉(ESR).结果重症肺炎组FDP及D-D明显升高,PCT、CRP、ESR水平升高,与正常对照组比较差异有统计学意义(P＜0.05).结论重症肺炎患者存在凝血纤溶系统功能的紊乱与炎症反应有关,FDP和D-D反应凝血纤溶系统的功能,注意FDP、D-D及炎症指标的变化在重症肺炎病情评估及指导治疗中具有一定价值.
목적 탐토중증폐염환자섬용계통공능화염증지표적변화급림상의의.방법 선취2013년6월지2014년6월기간입주정주대학제일부속의원RICU적40례중증폐염환자여본원체검중심동기40례건강체검자작위연구대상,분별측정기혈청중적섬유단백원강해산물(FDP)、D-이취체(D-D)、강개소원(PCT)、C-반응단백(CRP)、혈침(ESR).결과 중증폐염조FDP급D-D명현승고,PCT、CRP、ESR수평승고,여정상대조조비교차이유통계학의의(P＜0.05).결론 중증폐염환자존재응혈섬용계통공능적문란여염증반응유관,FDP화D-D반응응혈섬용계통적공능,주의FDP、D-D급염증지표적변화재중증폐염병정평고급지도치료중구유일정개치.
Objective To observe the change of fibrinolytic system function,D-dimer and inflammatory index in the patients with severe pneumonia,and to investigate the clinical significance.Methods Forty patients with severe pnemonia from June 2013 to June 2014 in the RICU in the first affiliated hospital of Zhengzhou university and forty cases of health check-up in the same period in the physical examination center were selected.The fibrinogen degradation (FDP),D-dimer (D-D),procalcitonin (PCT),C-reactive protien(CRP),erythrocyte sedimentation rate (ESR) in the serum were tested.Results Campared with the control group,the FDP and D-D significanty increased and the value of PCT,CRP,ESR elevated in the group with severe pneumonia(P ＜0.05).Conclusions The FDP and the D-D can reflect the function of blood coagulation system.The mechanism of coagulation and fibrinolytic function becomes disorder for the patients with severe pneumonia,which is related to the inflamamation.So observation for the changes of the above indexes might be helpful for the conditon assessment and the treatment.