中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
8期
22-23
,共2页
腺苷蛋氨酸%糖皮质激素%药物性胆汁淤积性肝病
腺苷蛋氨痠%糖皮質激素%藥物性膽汁淤積性肝病
선감단안산%당피질격소%약물성담즙어적성간병
Adenosylmethionine%Glucocorticoids%Drug-induced cholestatic liver disease
目的 探讨腺苷蛋氨酸联合糖皮质激素治疗药物性胆汁淤积性肝病的临床疗效.方法 选取2011年3月至2013年3月河南平煤神马医疗集团总医院肝病科门诊收治的78例药物性胆汁淤积性肝病患者,按照入院先后顺序分为观察组40例和对照组38例,对照组给予常规保肝治疗,观察组在此基础上联合腺苷蛋氨酸和糖皮质激素用药治疗,观察两组TBIL、ALP、AKP、GGT等肝功能指标及临床治疗疗效.结果 两组治疗后TBIL、ALP、ALT、GGT等肝功能指标较治疗前均得到改善(P＜0.05),但观察组在上述指标改善幅度方面明显大于对照组,差异有统计学意义(P＜0.05).观察组治疗总有效率为90.0％,明显高于对照组的78.9％ (P ＜0.05).观察组在治疗过程中出现3例药物不良反应.结论 早期联合应用腺苷蛋氨酸和糖皮质激素,发挥二者的协同作用,有助于缓解药物毒性对肝脏的持久损伤,见效快.不过建议临床对联合用药的做法作进一步研究,以验证推广可能性.
目的 探討腺苷蛋氨痠聯閤糖皮質激素治療藥物性膽汁淤積性肝病的臨床療效.方法 選取2011年3月至2013年3月河南平煤神馬醫療集糰總醫院肝病科門診收治的78例藥物性膽汁淤積性肝病患者,按照入院先後順序分為觀察組40例和對照組38例,對照組給予常規保肝治療,觀察組在此基礎上聯閤腺苷蛋氨痠和糖皮質激素用藥治療,觀察兩組TBIL、ALP、AKP、GGT等肝功能指標及臨床治療療效.結果 兩組治療後TBIL、ALP、ALT、GGT等肝功能指標較治療前均得到改善(P＜0.05),但觀察組在上述指標改善幅度方麵明顯大于對照組,差異有統計學意義(P＜0.05).觀察組治療總有效率為90.0％,明顯高于對照組的78.9％ (P ＜0.05).觀察組在治療過程中齣現3例藥物不良反應.結論 早期聯閤應用腺苷蛋氨痠和糖皮質激素,髮揮二者的協同作用,有助于緩解藥物毒性對肝髒的持久損傷,見效快.不過建議臨床對聯閤用藥的做法作進一步研究,以驗證推廣可能性.
목적 탐토선감단안산연합당피질격소치료약물성담즙어적성간병적림상료효.방법 선취2011년3월지2013년3월하남평매신마의료집단총의원간병과문진수치적78례약물성담즙어적성간병환자,안조입원선후순서분위관찰조40례화대조조38례,대조조급여상규보간치료,관찰조재차기출상연합선감단안산화당피질격소용약치료,관찰량조TBIL、ALP、AKP、GGT등간공능지표급림상치료료효.결과 량조치료후TBIL、ALP、ALT、GGT등간공능지표교치료전균득도개선(P＜0.05),단관찰조재상술지표개선폭도방면명현대우대조조,차이유통계학의의(P＜0.05).관찰조치료총유효솔위90.0％,명현고우대조조적78.9％ (P ＜0.05).관찰조재치료과정중출현3례약물불량반응.결론 조기연합응용선감단안산화당피질격소,발휘이자적협동작용,유조우완해약물독성대간장적지구손상,견효쾌.불과건의림상대연합용약적주법작진일보연구,이험증추엄가능성.
Objective To evaluate the clinical efficacy of adenosylmethionine combined with glucocorticoid on drug-induced cholestatic liver disease.Methods Seventy-eight patients with drug-induced cholestasis cholestatic liver disease from March 2011 to March 2013 were chosen and divided into observation group and control group according to the time of them to be admitted in the hospital.The control group received conventional liver protection treatment and observation group were given ademetionine combined with glucocorticoid on this basis.TBIL,ALP,AKP and GGT levels of the two groups before and after intervention were tested.Results After treatment,the levels of TBIL,ALP,ALT and GGT all decreased after treatment(P ＜ 0.05),and the improvement in observation group was more significant; the difference was significant(P ＜0.05).The effective rate of observation group was 90.0％,and the rate was 78.9％ in control group(P ＜0.05).Three cases of adverse drug reactions occurred in observation group during treatment.Conclusions Adenosylmethionine combined with glucocorticoid in the early treatment of drug-induced cholestatic liver disease can help alleviate drug toxicity lasting damage to the liver in short-term.However,further study is recommended in terms of the combination therapy to validate the promotion value.
