中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2015年
8期
50-51
,共2页
法舒地尔%急性脑梗死%超敏C反应蛋白%血浆血管内皮素-1%肿瘤坏死因子-α
法舒地爾%急性腦梗死%超敏C反應蛋白%血漿血管內皮素-1%腫瘤壞死因子-α
법서지이%급성뇌경사%초민C반응단백%혈장혈관내피소-1%종류배사인자-α
Fasudil%Acute cerebral infarction%High-sensitivity C-reactive protein%Endothelin-1%Tumor necrosis factor-α
目的 研究法舒地尔对急性脑梗死患者超敏C反应蛋白(hs-CRP)、内皮素-1(ET-1)、肿瘤坏死因子-α(TNF-α)水平的影响,以期探索急性脑梗死更加有效的治疗方法.方法 选择2012年4月至2014年4月许昌市中心医院神经内科收治的60例急性脑梗死患者为研究对象,随机分为观察组和对照组,每组30例.对照组所有患者在入院后均给予合理的抗血小板聚集、他汀类、活血化瘀、脑保护剂等常规治疗,观察组患者在上述常规治疗基础上加用法舒地尔治疗.分别于治疗前后测定患者神经功能缺损程度(NIHSS)、血清hs-CRP、ET-1以及TNF-α水平.结果 治疗后两组患者hs-CRP、ET-1、TNF-α水平及NIHSS评分四项指标均得到显著下降,与本组治疗前相比差异有统计学意义(P＜0.05).且治疗后观察组患者hs-CRP(4.2±1.5) mg/L、ET-1(73.5±20.4)ng/L、TNF-α(1.2±0.3) μg/L、NIHSS(8.5±5.6)评分显著低于对照组,差异有统计学意义(P＜0.05).结论 对于急性脑梗死患者法舒地尔能有效降低血清hs-CRP、ET-1以及TNF-α水平,缓解神经功能受损,提高脑梗死患者预后转归.
目的 研究法舒地爾對急性腦梗死患者超敏C反應蛋白(hs-CRP)、內皮素-1(ET-1)、腫瘤壞死因子-α(TNF-α)水平的影響,以期探索急性腦梗死更加有效的治療方法.方法 選擇2012年4月至2014年4月許昌市中心醫院神經內科收治的60例急性腦梗死患者為研究對象,隨機分為觀察組和對照組,每組30例.對照組所有患者在入院後均給予閤理的抗血小闆聚集、他汀類、活血化瘀、腦保護劑等常規治療,觀察組患者在上述常規治療基礎上加用法舒地爾治療.分彆于治療前後測定患者神經功能缺損程度(NIHSS)、血清hs-CRP、ET-1以及TNF-α水平.結果 治療後兩組患者hs-CRP、ET-1、TNF-α水平及NIHSS評分四項指標均得到顯著下降,與本組治療前相比差異有統計學意義(P＜0.05).且治療後觀察組患者hs-CRP(4.2±1.5) mg/L、ET-1(73.5±20.4)ng/L、TNF-α(1.2±0.3) μg/L、NIHSS(8.5±5.6)評分顯著低于對照組,差異有統計學意義(P＜0.05).結論 對于急性腦梗死患者法舒地爾能有效降低血清hs-CRP、ET-1以及TNF-α水平,緩解神經功能受損,提高腦梗死患者預後轉歸.
목적 연구법서지이대급성뇌경사환자초민C반응단백(hs-CRP)、내피소-1(ET-1)、종류배사인자-α(TNF-α)수평적영향,이기탐색급성뇌경사경가유효적치료방법.방법 선택2012년4월지2014년4월허창시중심의원신경내과수치적60례급성뇌경사환자위연구대상,수궤분위관찰조화대조조,매조30례.대조조소유환자재입원후균급여합리적항혈소판취집、타정류、활혈화어、뇌보호제등상규치료,관찰조환자재상술상규치료기출상가용법서지이치료.분별우치료전후측정환자신경공능결손정도(NIHSS)、혈청hs-CRP、ET-1이급TNF-α수평.결과 치료후량조환자hs-CRP、ET-1、TNF-α수평급NIHSS평분사항지표균득도현저하강,여본조치료전상비차이유통계학의의(P＜0.05).차치료후관찰조환자hs-CRP(4.2±1.5) mg/L、ET-1(73.5±20.4)ng/L、TNF-α(1.2±0.3) μg/L、NIHSS(8.5±5.6)평분현저저우대조조,차이유통계학의의(P＜0.05).결론 대우급성뇌경사환자법서지이능유효강저혈청hs-CRP、ET-1이급TNF-α수평,완해신경공능수손,제고뇌경사환자예후전귀.
Objective To investigate the effects of fasudil on serum levels of high-sensitivity Creactive protein,endothelin-1 and tumor necrosis factor-α,in order to investigate the more effective ways of acute cerebral infarction.Methods Sixty patients with acute cerebral infarction in the department of Neurology in our hospital from April 2012 to April 2014 were randomly divided into the observation group and control group,with 30 cases in each group.The patients in control group were treated with reasonable anti-platelet aggregation,Statin,blood circulation,neuroprotective agents and other conventional treatment,and the patients in observation group were treated with fasudil on the basis of the above conventional therapy.The neurological impairment (NIHSS),serum hs-CRP,ET-1 and TNF-α levels of the two groups were analyzed.Results After treatment,the hs-CRP,ET-1,TNF-α,NIHSS score of the two groups significantly decreased compared with before treatment,there were significant differences (P ＜0.01).The hs-CRP [(4.2±1.5) mg/L],ET-1 [(73.5 ±20.4) ng/L],TNF-α [(1.2 ±0.3)μg/L],NIHSS (8.5 ± 5.6) of observation group was significantly lower than those of the control group (P ＜0.05).Conclusions Fasudil can effectively reduce the serum hs-CRP,ET-1 and TNF-α levels,relieve neurological damage and improve the prognosis of patients with cerebral infarction.
