激光生物学报
激光生物學報
격광생물학보
ACTA LASER BIOLOGY SINICA
2015年
2期
186-190
,共5页
动脉粥样硬化%川穹内酯%阿托伐他汀
動脈粥樣硬化%川穹內酯%阿託伐他汀
동맥죽양경화%천궁내지%아탁벌타정
atherosclerotic%Ligusticumchuanxionghort%atorvastatin
目的：分析川穹内酯联合阿托伐他汀对VCAM-1和PAI-1的抑制作用，并研究两类药物联用对抗动脉粥样硬化的意义。方法：以2010年5月-2013年5月间于我院接受治疗的198例动脉粥样硬化为研究对象，以随机数字表法将其划分为观察组和对照组；对照组患者在常规保守治疗的基础上联用阿托伐他汀；观察组在对照组的基础上联用川穹内酯。对比治疗前后VCAM-1和PAI-1的血清浓度变化，统计血液生化检测及超声动脉检测结果。结果：①治疗后，两组患者两指标均上升，检测发现观察组VCAM-1和PAI-1明显低于对照组，组间差异具备统计学意义（P＜0．05）。②TC、LDL-C、HDL-C及颈动脉IMT和斑块Crous积分的变化均显示，观察组各指标改善情况明显优于对照组，对比差异均显著（P＜0．05）。结论：以川穹内酯联合阿托伐他汀；可有效抑制VCAM-1和PAI-1的表达；提升动脉粥样硬化治疗效果。
目的：分析川穹內酯聯閤阿託伐他汀對VCAM-1和PAI-1的抑製作用，併研究兩類藥物聯用對抗動脈粥樣硬化的意義。方法：以2010年5月-2013年5月間于我院接受治療的198例動脈粥樣硬化為研究對象，以隨機數字錶法將其劃分為觀察組和對照組；對照組患者在常規保守治療的基礎上聯用阿託伐他汀；觀察組在對照組的基礎上聯用川穹內酯。對比治療前後VCAM-1和PAI-1的血清濃度變化，統計血液生化檢測及超聲動脈檢測結果。結果：①治療後，兩組患者兩指標均上升，檢測髮現觀察組VCAM-1和PAI-1明顯低于對照組，組間差異具備統計學意義（P＜0．05）。②TC、LDL-C、HDL-C及頸動脈IMT和斑塊Crous積分的變化均顯示，觀察組各指標改善情況明顯優于對照組，對比差異均顯著（P＜0．05）。結論：以川穹內酯聯閤阿託伐他汀；可有效抑製VCAM-1和PAI-1的錶達；提升動脈粥樣硬化治療效果。
목적：분석천궁내지연합아탁벌타정대VCAM-1화PAI-1적억제작용，병연구량류약물련용대항동맥죽양경화적의의。방법：이2010년5월-2013년5월간우아원접수치료적198례동맥죽양경화위연구대상，이수궤수자표법장기화분위관찰조화대조조；대조조환자재상규보수치료적기출상련용아탁벌타정；관찰조재대조조적기출상련용천궁내지。대비치료전후VCAM-1화PAI-1적혈청농도변화，통계혈액생화검측급초성동맥검측결과。결과：①치료후，량조환자량지표균상승，검측발현관찰조VCAM-1화PAI-1명현저우대조조，조간차이구비통계학의의（P＜0．05）。②TC、LDL-C、HDL-C급경동맥IMT화반괴Crous적분적변화균현시，관찰조각지표개선정황명현우우대조조，대비차이균현저（P＜0．05）。결론：이천궁내지연합아탁벌타정；가유효억제VCAM-1화PAI-1적표체；제승동맥죽양경화치료효과。
Objectives:To analysis the effect of resistance to VCAM-1 and PAI-1 from LigusticumchuanxiongHort com-bined with atorvastatin,as well as the effect of anti-atherosclerotic from them.Methods:We chose 198 cases of athero-sclerosis accepted by our hospital during May 2010 to May 2013 as the research object.Patients selected treatment scheme on their own accords,and by which we divided them into observation group and control group.Patients in control group used conventional conservative treatment to treat disease,while patients in Observation Group applied Ligusticum-chuanxiongHort on the basis of the observation group.We compared the change of serum concentration of VCAM-1 and PAI-1 ,and made an account of blood biochemical testing and ultrasonic testing results.Then,we evaluated the efficacy of the treatment of atherosclerosis.Results:(1 )After treatment,patients in both groups increased by two indicators,the observation group detected VCAM-1 and PAI-1 was significantly lower than the control group,with statistically significant differences between groups (P<0.05).(2)The change of main indicators of atherosclerosis data:TC,LDL-C,HDL-C and carotid’s IMT as well as plaque’s Crous score,in observation group were much better than the change in Control Group,contrast differences were significantly (P<0.05).Conclusion:Combining LigusticumchuanxiongHort with ator-vastatin as treatment scheme can decline the amount of VCAM-1 and PAI-1 much better than using atorvastatin alone. And the combination can also improve the curative effect towards atherosclerotic,which has promotion value.
