中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
13期
1-3
,共3页
食管肿瘤%鳞状细胞癌%预后%中性粒细胞与淋巴细胞比值%放射疗法
食管腫瘤%鱗狀細胞癌%預後%中性粒細胞與淋巴細胞比值%放射療法
식관종류%린상세포암%예후%중성립세포여림파세포비치%방사요법
Esophageal neoplasms%Carcinoma squamous cell%Prognosis%Neutrophil-to-lymphocyte ratio%Radiotherapy
目的：探讨放射治疗前外周血中性粒细胞与淋巴细胞比值(NLR)在食管鳞状细胞癌患者预后评估中的价值。方法：回顾性分析2008年5月-2011年11月在徐州医学院附属医院放疗科住院确诊为食管鳞状细胞癌的149例患者的临床资料。NLR的临界值定义为3.0，其中NLR≥3.0的32例患者设为高NLR组，NLR<3.0的117例患者设为低NLR组。观察比较两组患者的放疗近期疗效及3年生存率。结果：高NLR组患者的近期总有效率为34.4%(11/32)，明显低于低NLR组患者的58.1%(68/117)，差异有统计学意义(P<0.05)。高NLR组患者的3年生存率为18.8%(6/32)，明显低于低NLR组患者的37.6%(44/117)，差异有统计学意义(P<0.05)。结论：放射治疗前外周血NLR≥3.0提示食管鳞状细胞癌患者预后不良。
目的：探討放射治療前外週血中性粒細胞與淋巴細胞比值(NLR)在食管鱗狀細胞癌患者預後評估中的價值。方法：迴顧性分析2008年5月-2011年11月在徐州醫學院附屬醫院放療科住院確診為食管鱗狀細胞癌的149例患者的臨床資料。NLR的臨界值定義為3.0，其中NLR≥3.0的32例患者設為高NLR組，NLR<3.0的117例患者設為低NLR組。觀察比較兩組患者的放療近期療效及3年生存率。結果：高NLR組患者的近期總有效率為34.4%(11/32)，明顯低于低NLR組患者的58.1%(68/117)，差異有統計學意義(P<0.05)。高NLR組患者的3年生存率為18.8%(6/32)，明顯低于低NLR組患者的37.6%(44/117)，差異有統計學意義(P<0.05)。結論：放射治療前外週血NLR≥3.0提示食管鱗狀細胞癌患者預後不良。
목적：탐토방사치료전외주혈중성립세포여림파세포비치(NLR)재식관린상세포암환자예후평고중적개치。방법：회고성분석2008년5월-2011년11월재서주의학원부속의원방료과주원학진위식관린상세포암적149례환자적림상자료。NLR적림계치정의위3.0，기중NLR≥3.0적32례환자설위고NLR조，NLR<3.0적117례환자설위저NLR조。관찰비교량조환자적방료근기료효급3년생존솔。결과：고NLR조환자적근기총유효솔위34.4%(11/32)，명현저우저NLR조환자적58.1%(68/117)，차이유통계학의의(P<0.05)。고NLR조환자적3년생존솔위18.8%(6/32)，명현저우저NLR조환자적37.6%(44/117)，차이유통계학의의(P<0.05)。결론：방사치료전외주혈NLR≥3.0제시식관린상세포암환자예후불량。
Objective:To investigate the prognostic significance of neutrophil-to-lymphocyte ratio(NLR) in patients with esophageal squamous cell carcinoma(ESCC) who received radiotherapy.Method:The clinical data of 149 patients with ESCC in Department of Radiotherapy of the Affiliated Hospital of Xuzhou Medical College from May 2008 to November 2011 were analyzed retrospectively.Based on this cut-off value of 3.0,all the patients were divided into the two groups:32 cases with NLR ≥ 3.0 were regarded as the high NLR group,117 cases with NLR<3.0 were regarded as the low NLR group.The short-term efficacy of radiotherapy and 3-year survival rate between the two groups were observed and compared.Result:The objective response rate(RR) of the high NLR group was 34.4%(11/32),which was significantly lower than 58.1%(68/117) of the low NLR group,the difference was statistically significant(P<0.05).The 3-year survival rate in the high NLR group was 18.8%(6/32),which was significantly lower than 37.6%(44/117) of the low NLR group,the difference was statistically significant(P<0.05).Conclusion:The results show that NLR≥3.0 may be a prognostic marker in patients with ESCC.
