CAJ | 학술논문

目的：探讨甲基强的松龙(MP)冲击治疗与小剂量地塞米松治疗急性脊髓损伤的疗效与早期并发症。方法选择2011年1月~2014年1月我院急诊创伤外科收治的68例急性脊髓损伤患者，按治疗方法分为MP冲击治疗组(实验组)和小剂量地塞米松治疗组(对照组)，比较两组的疗效及早期并发症。结果两组患者在接受治疗后早期神经功能都有一定恢复，但两组疗效近似，差异无统计学意义，实验组感染并发症的发生率高于对照组，高血糖的发生率也高于对照组，差异具有统计学意义(P<0.05)。消化道出血发生率无明显增加。结论早期使用MP冲击疗法治疗急性脊髓损伤不能明显改善患者的神经功能，反而增加感染和高血糖的发生率。
목적：탐토갑기강적송룡(MP)충격치료여소제량지새미송치료급성척수손상적료효여조기병발증。방법선택2011년1월~2014년1월아원급진창상외과수치적68례급성척수손상환자，안치료방법분위MP충격치료조(실험조)화소제량지새미송치료조(대조조)，비교량조적료효급조기병발증。결과량조환자재접수치료후조기신경공능도유일정회복，단량조료효근사，차이무통계학의의，실험조감염병발증적발생솔고우대조조，고혈당적발생솔야고우대조조，차이구유통계학의의(P<0.05)。소화도출혈발생솔무명현증가。결론조기사용MP충격요법치료급성척수손상불능명현개선환자적신경공능，반이증가감염화고혈당적발생솔。
Objective To explore the effects of methylprednisolone(MP) and early complications of shock treatment with small dose dexamethasone in treatment of acute spinal cord injury. Methods 68 cases of acute spinal cord injury were divided into the impact of the MP treatment group(experimental group) and low dose dexamethasone treatment group(control group) in our hospital from January 2011 to January 2014 , the efficacy and early complications were compared between the two groups. Results Two groups of patients had recovered in the early neural function after treatment, but the two groups had similar efficacy, no statistically significant difference occurred in experimental group, infection complication rate was higher than the control group, the rate of hyperglycemia was higher than that of the control group,the difference was significant between two troups(P<0.05). Gastrointestinal bleeding incidence was signif-icantly increased. Conclusion The early use of MP pulse therapy in the treatment of acute spinal cord injury patients cannot significantly improve the neural function, but increase the incidence of infection and hyperglycemia.