CAJ | 학술논문

目的：分析血清糖链抗原153(CA153)与人附睾分泌蛋白4(HE4)在宫颈癌患者血清中的表达。方法以我院2010年6月~2013年7月收治的72例宫颈癌患者作为研究对象，根据病理检查结果分为宫颈癌组(36例)、宫颈良性病变组(36例)，并将同期进行体检的36例健康女性作为对照组，检测对比三组血清CA153和HE4的含量。结果宫颈癌组患者血清CA153含量为(79.6±14.8)U/mL，显著高于宫颈良性病变组(t=5.17，P<0.05)和对照组(t=7.31，P<0.05)，差异具有统计学意义；宫颈癌患者血清HE4含量为(216.3±8.1)pmol/L，显著高于宫颈良性病变组(t=9.71，P<0.05)和对照组(t=11.84，P<0.05)，差异具有统计学意义；联合检测的阳性率显著高于单独检测，差异具有统计学意义(字2=4.527，P<0.05)；宫颈癌组不同分期患者血清CA153和HE4的水平分析显示，芋/郁期患者的血清中CA153和HE4要显著高于Ⅰ期Ⅱ期(P<0.05)。结论 CA153与HE4在宫颈癌患者血清中的含量显著升高。两者联合检测能够显著提高宫颈癌的诊断敏感性、特异性和诊断符合率，对于宫颈癌的早期诊断和治疗有重要的参考价值。
목적：분석혈청당련항원153(CA153)여인부고분비단백4(HE4)재궁경암환자혈청중적표체。방법이아원2010년6월~2013년7월수치적72례궁경암환자작위연구대상，근거병리검사결과분위궁경암조(36례)、궁경량성병변조(36례)，병장동기진행체검적36례건강녀성작위대조조，검측대비삼조혈청CA153화HE4적함량。결과궁경암조환자혈청CA153함량위(79.6±14.8)U/mL，현저고우궁경량성병변조(t=5.17，P<0.05)화대조조(t=7.31，P<0.05)，차이구유통계학의의；궁경암환자혈청HE4함량위(216.3±8.1)pmol/L，현저고우궁경량성병변조(t=9.71，P<0.05)화대조조(t=11.84，P<0.05)，차이구유통계학의의；연합검측적양성솔현저고우단독검측，차이구유통계학의의(자2=4.527，P<0.05)；궁경암조불동분기환자혈청CA153화HE4적수평분석현시，우/욱기환자적혈청중CA153화HE4요현저고우Ⅰ기Ⅱ기(P<0.05)。결론 CA153여HE4재궁경암환자혈청중적함량현저승고。량자연합검측능구현저제고궁경암적진단민감성、특이성화진단부합솔，대우궁경암적조기진단화치료유중요적삼고개치。
Objective To analyze the expression of serum carbohydrate antigen 153(CA153) and human epididymis protein 4 (HE4) in the cervical cancer patients. Methods 72 cases of cervix neoplasms patients received from Jun 2010 to July 2013,were divided into the cervical cancer group(36 cases)and cervical benign lesions group(36 cases)according to different pathological results, 36 cases of healthy women undergoing physical examination at the same time were chosen as control group. The level of serum CA153 and HE4 of above research subjects were detected and analyzed. Results The level of serum CA153 of cervical cancer group(79.6±14.8)U/mL was higher than that of cervical benign lesions group (t=5.17, P<0.05) and control group (t=7.31, P<0.05), there was statistically significant differ-ence; the level of serum HE4 of cervical cancer grou (216.3±8.1) pmol/L was higher that of cervical benign lesions group(t=9.71,P<0.05) and control group (t=11.84, P<0.05), there was statistically significant difference; the posi-tive rate of combined detection was higher than that of single detection, there was statistically significant difference(χ2=4.527,P<0.05); The level of serum CA153 and HE4 in III/IV stage were higher than that in I/II stage, and the difference was statistically significant (P<0.05). Conclusion The level of serum CA153 and HE4 of cervical cancer patients increase significantly. The combined detection of CA153 and HE4 can improve the diagnostic sensitivity,specificity and accordance rate of cervical cancer prominently,so it has great reference value in the early diagnosis and treatment of cervical cancer.